Jiang Qiu, Liu Jie, Huang Shan, Wang Xuan-Yue, Chen Xiaowei, Liu Guang-Hui, Ye Keqiang, Song Weihong, Masters Colin L, Wang Jun, Wang Yan-Jiang
Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China.
Signal Transduct Target Ther. 2025 Mar 10;10(1):76. doi: 10.1038/s41392-025-02145-7.
In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer's disease (AD), is increasing. However, the current symptomatic and disease-modifying therapies have achieved limited benefits for neurodegenerative diseases in clinical settings. Halting the progress of neurodegeneration and cognitive decline or even improving impaired cognition and function are the clinically meaningful goals of treatments for neurodegenerative diseases. Ageing is the primary risk factor for neurodegenerative diseases and their associated comorbidities, such as vascular pathologies, in elderly individuals. Thus, we aim to elucidate the role of ageing in neurodegenerative diseases from the perspective of a complex system, in which the brain is the core and peripheral organs and tissues form a holistic network to support brain functions. During ageing, the progressive deterioration of the structure and function of the entire body hampers its active and adaptive responses to various stimuli, thereby rendering individuals more vulnerable to neurodegenerative diseases. Consequently, we propose that the prevention and treatment of neurodegenerative diseases should be grounded in holistic antiageing and rejuvenation means complemented by interventions targeting disease-specific pathogenic events. This integrated approach is a promising strategy to effectively prevent, pause or slow down the progression of neurodegenerative diseases.
在全球老龄化的背景下，神经退行性疾病和痴呆症（如阿尔茨海默病）的患病率正在上升。然而，目前的对症治疗和疾病修饰疗法在临床环境中对神经退行性疾病的益处有限。阻止神经退行性变和认知衰退的进展，甚至改善受损的认知和功能，是神经退行性疾病治疗的临床意义目标。衰老在老年个体中是神经退行性疾病及其相关合并症（如血管病变）的主要危险因素。因此，我们旨在从复杂系统的角度阐明衰老在神经退行性疾病中的作用，其中大脑是核心，外周器官和组织形成一个整体网络来支持大脑功能。在衰老过程中，全身结构和功能的逐渐恶化阻碍了其对各种刺激的积极和适应性反应，从而使个体更容易患神经退行性疾病。因此，我们建议神经退行性疾病的预防和治疗应以整体抗衰和年轻化手段为基础，并辅以针对疾病特异性致病事件的干预措施。这种综合方法是有效预防、暂停或减缓神经退行性疾病进展的有前景的策略。
