干扰素α/β在小鼠肠道病理诱导中的作用。

The role of interferon alpha/beta in the induction of intestinal pathology in mice.

作者信息

Garside P, Felstein M V, Green E A, Mowat A M

机构信息

Department of Immunology, University of Glasgow, Western Infirmary.

出版信息

Immunology. 1991 Oct;74(2):279-83.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384605/

Abstract

We have investigated the role of interferon-alpha/beta (IFN-alpha/beta) and IFN-dependent effector cells in causing enteropathy in mice. The IFN-inducer polyinosinic:polycytydylic acid (poly I:C) augmented the natural killer (NK) cell activation normally seen in neonatal (CBA x BALB/c)F1 mice with graft-versus-host reaction (GVHR) and exacerbated the systemic and intestinal consequences of GVHR. Poly I:C itself produced a similar pattern of intestinal pathology when administered to normal mice. The effects of poly I:C on NK cell activity and intestinal architecture in normal mice could be reproduced by a single injection of purified IFN-alpha/beta and the intestinal lesions caused by IFN-alpha/beta were prevented by in vivo depletion of NK cells with anti-asialo GM1. These results indicate that IFN-alpha/beta may play an important role in immunologically mediated enteropathies by virtue of its ability to activate NK cells.

摘要

我们研究了α/β干扰素（IFN-α/β）和IFN依赖性效应细胞在小鼠肠道病变形成中的作用。IFN诱导剂聚肌苷酸:聚胞苷酸（poly I:C）增强了新生（CBA×BALB/c）F1小鼠移植物抗宿主反应（GVHR）中自然杀伤（NK）细胞的正常活化，并加剧了GVHR的全身和肠道后果。当给予正常小鼠时，poly I:C本身也产生了类似的肠道病理模式。单次注射纯化的IFN-α/β可重现poly I:C对正常小鼠NK细胞活性和肠道结构的影响，并且通过用抗唾液酸GM1体内清除NK细胞可预防IFN-α/β引起的肠道病变。这些结果表明，IFN-α/β可能因其激活NK细胞的能力而在免疫介导的肠道病变中起重要作用。

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本文引用的文献

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Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.小肠中的超敏反应。6. 小鼠小肠黏膜移植物抗宿主反应的发病机制。

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Augmentation of intestinal and peripheral natural killer cell activity during the graft-versus-host reaction in mice.小鼠移植物抗宿主反应期间肠道和外周自然杀伤细胞活性的增强。

Transplantation. 1983 Nov;36(5):513-9. doi: 10.1097/00007890-198311000-00009.

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Prevention of lethal, minor-determinate graft-host disease in mice by the in vivo administration of anti-asialo GM1.通过体内给予抗唾液酸GM1预防小鼠致死性、微小决定性移植物抗宿主病。

J Immunol. 1983 Nov;131(5):2101-3.

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Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon.自然杀伤（NK）细胞衍生的造血集落抑制活性和NK细胞毒性因子。与肿瘤坏死因子的关系以及与免疫干扰素的协同作用。

J Exp Med. 1985 Nov 1;162(5):1512-30. doi: 10.1084/jem.162.5.1512.

5

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6

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