Govindan K, Smith J, Knowles L, Harvey A, Townsend P, Kenealy J
Department of Plastic and Reconstructive Surgery, Frenchay Hospital, Frenchay, Bristol, UK.
J Plast Reconstr Aesthet Surg. 2007;60(6):639-45. doi: 10.1016/j.bjps.2006.10.003. Epub 2007 Jan 31.
The incidence of malignant melanoma in the UK is rising. Increased awareness of melanoma has led to an increase in patients presenting with pigmented lesions to their general practitioner (GP) and to pigmented lesion clinics. The sensitivity and specificity of the general practitioner in diagnosing melanoma remains poor.
A trial was conducted to establish the effectiveness of SIAscope in triaging patients referred by GPs on suspicion of melanoma.
After Ethical Committee approval, all consenting patients attending the Pigmented Lesion Clinic at Frenchay Hospital were scanned with the SIAscope. The consultant then examined all the patients and all suspicious lesions were excised and examined.
Eight hundred and eighty-six patients were included in the trial. The SIAscope had a sensitivity of 94.4% with a false negative rate of 3.7% for malignant melanoma.
The SIAscope could be useful in reducing the number of benign lesions seen by the consultant while still identifying most melanomas.
英国恶性黑色素瘤的发病率正在上升。对黑色素瘤认识的提高导致向全科医生（GP）和色素沉着病变诊所就诊的色素沉着病变患者增多。全科医生诊断黑色素瘤的敏感性和特异性仍然很差。
进行一项试验以确定SIAscope在对全科医生怀疑患有黑色素瘤而转诊的患者进行分诊方面的有效性。
经伦理委员会批准后，对所有在弗伦奇医院色素沉着病变诊所就诊并同意参与的患者使用SIAscope进行扫描。然后由顾问对所有患者进行检查，所有可疑病变均被切除并检查。
886名患者纳入试验。SIAscope对恶性黑色素瘤的敏感性为94.4%，假阴性率为3.7%。
SIAscope有助于减少顾问医生检查的良性病变数量，同时仍能识别出大多数黑色素瘤。
