Xiao Gutian
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):233-43. doi: 10.1016/j.cytogfr.2007.04.006. Epub 2007 May 7.
Autophagy/macroautophagy is known for its role in cellular homeostasis, development, cell survival, aging, immunity, cancer and neurodegeneration. However, until recently, the mechanisms by which autophagy contributes to these important processes were largely unknown. The demonstration of a direct cross-talk between autophagy and NF-kappaB opens up new frontiers for deciphering the role of autophagy in diverse biological processes. Here, we review our current understanding of autophagy, with a focus on its role in tumor suppression, NF-kappaB inactivation and selective protein degradation in mammals. We also list some most intriguing and outstanding questions that are likely to engage researchers in the near future.
自噬/巨自噬因其在细胞稳态、发育、细胞存活、衰老、免疫、癌症和神经退行性变中的作用而闻名。然而，直到最近，自噬促进这些重要过程的机制在很大程度上仍不清楚。自噬与核因子κB之间直接相互作用的证明为解读自噬在多种生物学过程中的作用开辟了新的前沿领域。在这里，我们综述了目前对自噬的理解，重点关注其在哺乳动物肿瘤抑制、核因子κB失活和选择性蛋白质降解中的作用。我们还列出了一些最引人入胜且突出的问题，这些问题可能会在不久的将来吸引研究人员的关注。
