• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

介导自噬、炎症和细胞凋亡，以逃避宿主杀伤。

mediates autophagy, inflammation, and apoptosis to escape host killing.

机构信息

The College of Veterinary Medicine, Southwest University, Chongqing, China.

Animal Epidemic Prevention and Control Center of Rongchang, Chongqing, China.

出版信息

Front Cell Infect Microbiol. 2024 Oct 23;14:1408407. doi: 10.3389/fcimb.2024.1408407. eCollection 2024.

DOI:10.3389/fcimb.2024.1408407
PMID:39507949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11537862/
Abstract

Brucellosis is a serious zoonosis caused by spp. infection, which not only seriously jeopardizes the health of humans and mammals, but also causes huge economic losses to the livestock industry. is a Gram-negative intracellular bacterium that relies primarily on its virulence factors and a variety of evolved survival strategies to replicate and proliferate within cells. Currently, the mechanisms of autophagy, inflammation, and apoptosis in -infected hosts are not fully understood and require further research and discussion. This review focuses on the relationship between and autophagy, inflammation, and apoptosis to provide the scientific basis for revealing the pathogenesis of .

摘要

布鲁氏菌病是由 spp. 感染引起的一种严重的人畜共患病，不仅严重危害人类和哺乳动物的健康，也给畜牧业造成巨大的经济损失。 是一种革兰氏阴性胞内菌，主要依靠其毒力因子和多种进化的生存策略在细胞内复制和增殖。目前，宿主中被 感染后的自噬、炎症和细胞凋亡的机制尚不完全清楚，需要进一步研究和讨论。本综述重点探讨了 与自噬、炎症和细胞凋亡的关系，为揭示 的发病机制提供科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/cb95d4131aca/fcimb-14-1408407-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/02ccbcc1b7ea/fcimb-14-1408407-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/de3c86ec5763/fcimb-14-1408407-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/cb95d4131aca/fcimb-14-1408407-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/02ccbcc1b7ea/fcimb-14-1408407-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/de3c86ec5763/fcimb-14-1408407-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/cb95d4131aca/fcimb-14-1408407-g003.jpg

相似文献

1
mediates autophagy, inflammation, and apoptosis to escape host killing.介导自噬、炎症和细胞凋亡，以逃避宿主杀伤。
Front Cell Infect Microbiol. 2024 Oct 23;14:1408407. doi: 10.3389/fcimb.2024.1408407. eCollection 2024.
2
Establishment of Chronic Infection: Brucella's Stealth Strategy.慢性感染的建立：布鲁氏菌的隐匿策略。
Front Cell Infect Microbiol. 2016 Mar 15;6:30. doi: 10.3389/fcimb.2016.00030. eCollection 2016.
3
Innate immune encounters of the (Type) 4th kind: Brucella.先天免疫遭遇（第四种）类型：布鲁氏菌。
Cell Microbiol. 2010 Sep 1;12(9):1195-202. doi: 10.1111/j.1462-5822.2010.01498.x. Epub 2010 Jul 28.
4
Brucella virulence mechanisms and implications in novel vaccines and drugs.布鲁氏菌的毒力机制及其在新型疫苗和药物中的意义。
Crit Rev Eukaryot Gene Expr. 2013;23(1):49-64. doi: 10.1615/critreveukargeneexpr.2013006666.
5
The Mechanism of Facultative Intracellular Parasitism of .兼性细胞内寄生的机制。
Int J Mol Sci. 2021 Apr 1;22(7):3673. doi: 10.3390/ijms22073673.
6
Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of .宿主 IRE1α 依赖性信号轴的激活有助于 的细胞内寄生。
Front Cell Infect Microbiol. 2018 Apr 20;8:103. doi: 10.3389/fcimb.2018.00103. eCollection 2018.
7
Important biology events and pathways in Brucella infection and implications for novel antibiotic drug targets.布鲁氏菌感染中的重要生物学事件和途径及其对新型抗生素药物靶点的启示
Crit Rev Eukaryot Gene Expr. 2013;23(1):65-76. doi: 10.1615/critreveukargeneexpr.2013006580.
8
Interactions of the human pathogenic Brucella species with their hosts.人致病菌布鲁氏菌属与宿主的相互作用。
Annu Rev Microbiol. 2011;65:523-41. doi: 10.1146/annurev-micro-090110-102905.
9
Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions.布鲁氏菌病的发病机制与免疫生物学：布鲁氏菌与宿主相互作用的综述
Am J Pathol. 2015 Jun;185(6):1505-17. doi: 10.1016/j.ajpath.2015.03.003. Epub 2015 Apr 17.
10
Internal affairs: investigating the Brucella intracellular lifestyle.内务：探究布鲁氏菌的细胞内生活方式。
FEMS Microbiol Rev. 2012 May;36(3):533-62. doi: 10.1111/j.1574-6976.2012.00334.x. Epub 2012 Mar 22.

本文引用的文献

1
The Effector Protein BspF Regulates Apoptosis through the Crotonylation of p53.效应蛋白BspF通过p53的巴豆酰化调节细胞凋亡。
Microorganisms. 2023 Sep 15;11(9):2322. doi: 10.3390/microorganisms11092322.
2
Role of the cGAS/STING pathway in the control of infection acquired through the respiratory route.cGAS/STING 通路在控制呼吸道获得性感染中的作用。
Front Immunol. 2023 May 16;14:1116811. doi: 10.3389/fimmu.2023.1116811. eCollection 2023.
3
Host cell egress of Brucella abortus requires BNIP3L-mediated mitophagy.布鲁氏菌属 abortus 的宿主细胞外吐需要 BNIP3L 介导的线粒体自噬。
EMBO J. 2023 Jul 17;42(14):e112817. doi: 10.15252/embj.2022112817. Epub 2023 May 25.
4
Deletion of Brucella transcriptional regulator GntR10 regulated the expression of quorum sensing system and type IV secretion system effectors, which affected the activation of NF-κB.布鲁氏菌转录调控因子 GntR10 的缺失调控了群体感应系统和 IV 型分泌系统效应子的表达，从而影响了 NF-κB 的激活。
J Proteomics. 2023 Jul 15;283-284:104938. doi: 10.1016/j.jprot.2023.104938. Epub 2023 May 23.
5
Effect of ubiquitin-proteasome system and autophagy-lysosome pathway on intracellular replication of Brucella.suis.泛素-蛋白酶体系统和自噬溶酶体途径对猪布鲁氏菌体内复制的影响。
Vet Microbiol. 2023 May;280:109699. doi: 10.1016/j.vetmic.2023.109699. Epub 2023 Feb 16.
6
BtpB Manipulates Apoptosis and Autophagic Flux in RAW264.7 Cells.BtpB 调控 RAW264.7 细胞中的细胞凋亡和自噬流。
Int J Mol Sci. 2022 Nov 20;23(22):14439. doi: 10.3390/ijms232214439.
7
Crosstalk of Brucella abortus nucleomodulin BspG and host DNA replication process/mitochondrial respiratory pathway promote anti-apoptosis and infection.流产布鲁氏菌核调节蛋白BspG与宿主DNA复制过程/线粒体呼吸途径的相互作用促进抗凋亡和感染。
Vet Microbiol. 2022 May;268:109414. doi: 10.1016/j.vetmic.2022.109414. Epub 2022 Mar 30.
8
The VirB System Plays a Crucial Role in Intracellular Infection.VirB 系统在细胞内感染中起着至关重要的作用。
Int J Mol Sci. 2021 Dec 20;22(24):13637. doi: 10.3390/ijms222413637.
9
Nucleomodulin BspJ as an effector promotes the colonization of in the host.核基质蛋白 BspJ 作为效应因子促进 在宿主中的定植。
J Vet Sci. 2022 Jan;23(1):e8. doi: 10.4142/jvs.21224. Epub 2021 Oct 24.
10
Deletion of the type IV secretion system promoter in A19 strain attenuated the virulence of the bacteria and promotes autophagy.在 A19 株中删除 IV 型分泌系统启动子减弱了细菌的毒力，并促进了自噬。
Can J Microbiol. 2022 Mar;68(3):165-176. doi: 10.1139/cjm-2021-0053. Epub 2021 Oct 13.