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介导自噬、炎症和细胞凋亡,以逃避宿主杀伤。

mediates autophagy, inflammation, and apoptosis to escape host killing.

机构信息

The College of Veterinary Medicine, Southwest University, Chongqing, China.

Animal Epidemic Prevention and Control Center of Rongchang, Chongqing, China.

出版信息

Front Cell Infect Microbiol. 2024 Oct 23;14:1408407. doi: 10.3389/fcimb.2024.1408407. eCollection 2024.

Abstract

Brucellosis is a serious zoonosis caused by spp. infection, which not only seriously jeopardizes the health of humans and mammals, but also causes huge economic losses to the livestock industry. is a Gram-negative intracellular bacterium that relies primarily on its virulence factors and a variety of evolved survival strategies to replicate and proliferate within cells. Currently, the mechanisms of autophagy, inflammation, and apoptosis in -infected hosts are not fully understood and require further research and discussion. This review focuses on the relationship between and autophagy, inflammation, and apoptosis to provide the scientific basis for revealing the pathogenesis of .

摘要

布鲁氏菌病是由 spp. 感染引起的一种严重的人畜共患病,不仅严重危害人类和哺乳动物的健康,也给畜牧业造成巨大的经济损失。 是一种革兰氏阴性胞内菌,主要依靠其毒力因子和多种进化的生存策略在细胞内复制和增殖。目前,宿主中被 感染后的自噬、炎症和细胞凋亡的机制尚不完全清楚,需要进一步研究和讨论。本综述重点探讨了 与自噬、炎症和细胞凋亡的关系,为揭示 的发病机制提供科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbc/11537862/02ccbcc1b7ea/fcimb-14-1408407-g001.jpg

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