人体血液和组织中辅酶Q的分析。
Analysis of coenzyme Q in human blood and tissues.
作者信息
Barshop Bruce A, Gangoiti Jon A
机构信息
Department of Pediatrics, University of California San Diego, La Jolla, CA 92093-0830, USA.
出版信息
Mitochondrion. 2007 Jun;7 Suppl:S89-93. doi: 10.1016/j.mito.2007.04.002. Epub 2007 Apr 13.
The major coenzyme Q species in humans is the decaprenyl quinoid derivative coenzyme Q10 (CoQ10), and its measurement is somewhat challenging owing to its hydrophobicity and tendency to be oxidized. There are three major methods which are suited for analysis of CoQ10: HPLC-coupled UV or electrochemical detection, and tandem mass spectrometry. The techniques are discussed, and results of these applications to determine CoQ10 concentrations in various human fluids and tissues are summarized.
人类体内主要的辅酶Q种类是癸异戊二烯醌衍生物辅酶Q10（CoQ10），由于其疏水性和易被氧化的特性，对其进行测量颇具挑战性。有三种主要方法适用于CoQ10的分析：高效液相色谱联用紫外或电化学检测，以及串联质谱法。本文对这些技术进行了讨论，并总结了这些方法在测定各种人体体液和组织中CoQ10浓度方面的应用结果。
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