La Marca A, Giulini S, Orvieto R, De Leo V, Volpe A
Institute of Obstetrics and Gynecology, Policlinico of Modena, University of Modena and Reggio Emilia, Italy.
Hum Reprod. 2005 Jun;20(6):1569-72. doi: 10.1093/humrep/deh819. Epub 2005 Feb 25.
In females, anti-Müllerian hormone (AMH) is expressed only by the ovary. AMH is secreted by the granulosa cells of ovarian follicles and appears to regulate early follicle development. AMH is detected in serum from women of reproductive age and its levels vary slightly with the menstrual cycle, reaching the peak value in the late follicular phase. This study investigated serum AMH levels throughout gestation and after delivery in healthy pregnant women.
This cross-sectional study recruited pregnant women and healthy non-pregnant women, 84 in total. AMH, FSH and E2 were measured in the follicular phase, in the three trimesters of pregnancy and in early puerperium.
Estradiol and FSH levels followed the expected patterns during gestation. During the follicular phase of the menstrual cycle AMH levels were 1.9 +/- 0.5 ng/ml. In the three trimesters of pregnancy and in early puerperium AMH levels were: 2.1 +/- 0.56, 2.4 +/- 0.64, 1.95 +/- 0.6 and 2.05 +/- 0.55 ng/ml respectively. No significant modifications were found in AMH levels during pregnancy and in the early puerperium.
This study has obtained information on AMH and on the possible relationship with FSH. We hypothesize that the profile of the new marker of ovarian activity AMH may indicate that initial non-cyclic ovarian follicular activity during pregnancy is not abolished. Moreover FSH, does not seem to play a direct role on AMH synthesis and secretion.
在女性中，抗苗勒管激素（AMH）仅由卵巢分泌。AMH由卵巢卵泡的颗粒细胞分泌，似乎对早期卵泡发育起调节作用。在育龄女性的血清中可检测到AMH，其水平随月经周期略有变化，在卵泡晚期达到峰值。本研究调查了健康孕妇整个孕期及产后血清AMH水平。
这项横断面研究共招募了84名孕妇和健康非孕妇。在卵泡期、孕期三个阶段及产褥早期测量AMH、促卵泡生成素（FSH）和雌二醇（E2）水平。
孕期雌二醇和FSH水平呈预期模式。月经周期卵泡期AMH水平为1.9±0.5 ng/ml。孕期三个阶段及产褥早期AMH水平分别为：2.1±0.56、2.4±0.64、1.95±0.6和2.05±0.55 ng/ml。孕期及产褥早期AMH水平未发现显著变化。
本研究获得了关于AMH及其与FSH可能关系的信息。我们推测，卵巢活性新标志物AMH的情况可能表明孕期最初的非周期性卵巢卵泡活性并未消失。此外，FSH似乎对AMH的合成和分泌没有直接作用。
