Eguchi Kazuo, Schwartz Joseph E, Roman Mary J, Devereux Richard B, Gerin William, Pickering Thomas G
Center for Behavioral Cardiovascular Health and Hypertension Program, Columbia University Medical Center, New York, NY 10032, USA.
J Clin Hypertens (Greenwich). 2007 May;9(5):337-44. doi: 10.1111/j.1524-6175.2007.06474.x.
The authors investigated the associations between target organ damage and individual components of the metabolic syndrome (MS) compared with the MS itself. Carotid intima-media thickness (IMT), carotid plaque, and left ventricular mass index (LVMI) were assessed by ultrasonography in 356 participants who were free of overt cardiovascular disease. Participants with the MS (n=33) had higher LVMI and carotid IMT than those without the MS (n=323), but the percentage of patients who had carotid plaque was similar. Individually, each component of the MS was significantly associated with the 3 measures of target organ damage. In bivariate and multivariate analyses, the association of clinic systolic blood pressure to both LVMI and carotid IMT and the negative association of high-density lipoprotein cholesterol with carotid plaque were stronger than and independent of the MS. The data suggest that physicians should evaluate blood pressure and high-density lipoprotein cholesterol as well as other cardiovascular risk factors without regard to whether a patient meets the criteria for the MS.
作者研究了靶器官损害与代谢综合征（MS）的各个组成部分之间的关联，并与MS本身进行了比较。通过超声检查对356名无明显心血管疾病的参与者进行了颈动脉内膜中层厚度（IMT）、颈动脉斑块和左心室质量指数（LVMI）评估。患有MS的参与者（n = 33）的LVMI和颈动脉IMT高于未患MS的参与者（n = 323），但有颈动脉斑块的患者百分比相似。单独来看，MS的每个组成部分都与3种靶器官损害指标显著相关。在双变量和多变量分析中，临床收缩压与LVMI和颈动脉IMT的关联以及高密度脂蛋白胆固醇与颈动脉斑块的负关联比MS更强且独立于MS。数据表明，医生应评估血压、高密度脂蛋白胆固醇以及其他心血管危险因素，而无需考虑患者是否符合MS的标准。
