Hruban Ralph H, Fukushima Noriyoshi
Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Mod Pathol. 2007 Feb;20 Suppl 1:S61-70. doi: 10.1038/modpathol.3800685.
Pancreatic cancer is the fourth leading cause of cancer death in the US. Most pancreatic cancers are infiltrating ductal adenocarcinomas. The careful application of well-defined morphologic criteria can be used to differentiate between infiltrating ductal adenocarcinoma and reactive glands. While most pancreatic cancers are ductal adenocarcinomas, a number of histologically defined variants have been described. These are important to recognize because they have distinct clinical pathologic features. Pancreatic intraepithelial neoplasia (PanIN) is the presumed precursor lesion to infiltrating ductal adenocarcinoma, and PanIN lesions can mimic infiltrating cancer.
胰腺癌是美国癌症死亡的第四大主要原因。大多数胰腺癌是浸润性导管腺癌。仔细应用明确的形态学标准可用于区分浸润性导管腺癌和反应性腺。虽然大多数胰腺癌是导管腺癌，但已描述了一些组织学定义的变体。识别这些变体很重要，因为它们具有独特的临床病理特征。胰腺上皮内瘤变（PanIN）被认为是浸润性导管腺癌的前驱病变，并且PanIN病变可能会模仿浸润性癌。
