Olivero D K, Davidson M G, English R V, Nasisse M P, Jamieson V E, Gerig T M
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
J Am Vet Med Assoc. 1991 Oct 15;199(8):1039-42.
Keratoconjunctivitis sicca (KCS) is a prevalent and often vision-threatening condition in dogs. In several reports, 2% cyclosporine (cyclosporin A, CsA) was described as effective in modulating the clinical signs of KCS. This study was designed to compare the efficacy of 1% CsA vs a placebo, using a randomized double-blind clinical trial. Topical administration of 1% CsA significantly improved Schirmer wetting values and subjective markers of corneal health as compared with the placebo. In the dogs treated with topical administration of 1% CsA, the clinical signs of KCS were improved in 81.8% of cases.
犬干眼症（KCS）是一种在犬类中普遍存在且常威胁视力的病症。在多篇报道中，2%的环孢素（环孢菌素A，CsA）被描述为对调节KCS的临床症状有效。本研究旨在通过随机双盲临床试验比较1% CsA与安慰剂的疗效。与安慰剂相比，局部应用1% CsA显著提高了泪液分泌试验湿润值以及角膜健康的主观指标。在局部应用1% CsA治疗的犬只中，81.8%的病例KCS临床症状得到改善。
