Morgan R V, Abrams K L
Angell Memorial Animal Hospital, Boston, MA 02130.
J Am Vet Med Assoc. 1991 Oct 15;199(8):1043-6.
Sixty dogs with chronic keratoconjunctivitis sicca were treated by topical administration of 2% cyclosporine twice daily. Causes and duration of keratoconjunctivitis varied. Tear production improved in 75 of 100 eyes, and corneal pigmentation decreased in 45 of 67 eyes. Six factors were evaluated to determine their influence on treatment outcome. The only significant variable was the initial Schirmer tear test value. Side effects were few. Evidence of burning in response to application of cyclosporine resolved with change in the formulation of the topical solution.
对60只患有慢性干燥性角结膜炎的犬，每天两次局部给予2%环孢素进行治疗。角结膜炎的病因和病程各不相同。100只眼中有75只眼的泪液分泌得到改善，67只眼中有45只眼的角膜色素沉着减轻。评估了六个因素以确定它们对治疗结果的影响。唯一显著的变量是初始泪液分泌试验值。副作用很少。随着局部溶液配方的改变，应用环孢素后出现的烧灼感证据消失。
