Kapranov Philipp, Willingham Aarron T, Gingeras Thomas R
Affymetrix, Inc., 3420 Central Expressway, Santa Clara, California 95051, USA.
Nat Rev Genet. 2007 Jun;8(6):413-23. doi: 10.1038/nrg2083. Epub 2007 May 8.
Recent evidence of genome-wide transcription in several species indicates that the amount of transcription that occurs cannot be entirely accounted for by current sets of genome-wide annotations. Evidence indicates that most of both strands of the human genome might be transcribed, implying extensive overlap of transcriptional units and regulatory elements. These observations suggest that genomic architecture is not colinear, but is instead interleaved and modular, and that the same genomic sequences are multifunctional: that is, used for multiple independently regulated transcripts and as regulatory regions. What are the implications and consequences of such an interleaved genomic architecture in terms of increased information content, transcriptional complexity, evolution and disease states?
近期在多个物种中全基因组转录的证据表明，发生的转录量无法完全由当前的全基因组注释集来解释。有证据表明，人类基因组的两条链大部分可能都被转录，这意味着转录单元和调控元件存在广泛重叠。这些观察结果表明，基因组结构并非共线性的，而是交错且模块化的，并且相同的基因组序列具有多种功能：即用于多个独立调控的转录本以及作为调控区域。就信息含量增加、转录复杂性、进化和疾病状态而言，这种交错的基因组结构有哪些影响和后果呢？
