Musshoff Frank, Madea Burkhard
Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany.
Anal Bioanal Chem. 2007 Aug;388(7):1475-94. doi: 10.1007/s00216-007-1288-x. Epub 2007 May 8.
This review focuses on possible pitfalls in hair testing procedures. Knowledge of such pitfalls is useful when developing and validating methods, since it can be used to avoid wrong results as well as wrong interpretations of correct results. In recent years, remarkable advances in sensitive and specific analytical techniques have enabled the analysis of drugs in alternative biological specimens such as hair. Modern analytical procedures for the determination of drugs in hair specimens - mainly by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) - are reviewed and critically discussed. Many tables containing information related to this topic are provided.
本综述聚焦于毛发检测程序中可能存在的陷阱。了解这些陷阱对于方法的开发和验证很有用，因为它可用于避免错误结果以及对正确结果的错误解读。近年来，灵敏且特异的分析技术取得了显著进展，使得在毛发等替代生物样本中检测药物成为可能。本文对主要通过气相色谱 - 质谱联用（GC-MS）和液相色谱 - 质谱联用（LC-MS）测定毛发样本中药物的现代分析程序进行了综述并作批判性讨论。文中提供了许多包含与该主题相关信息的表格。
