Laboratory of Petroleomics and Forensics, Universidade Federal Do Espírito Santo (UFES), Av. Fernando Ferrari, 514, Goiabeiras, Vitória, Espírito Santo, 29075-910, Brazil.
Instituto Nacional de Ciência E Tecnologia Forense (INCT Forense), Vila Velha, Brazil.
Anal Bioanal Chem. 2024 Oct;416(24):5255-5280. doi: 10.1007/s00216-024-05470-y. Epub 2024 Aug 20.
Forensic chemistry literature has grown exponentially, with many analytical techniques being used to provide valuable information to help solve criminal cases. Among them, matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS), particularly MALDI MS imaging (MALDI MSI), has shown much potential in forensic applications. Due to its high specificity, MALDI MSI can analyze a wide variety of compounds in complex samples without extensive sample preparation, providing chemical profiles and spatial distributions of given analyte(s). This review introduces MALDI MS(I) to forensic scientists with a focus on its basic principles and the applications of MALDI MS(I) to the analysis of fingerprints, drugs of abuse, and their metabolites in hair, medicine samples, animal tissues, and inks in documents.
法医化学文献呈指数级增长，许多分析技术被用于提供有价值的信息，以帮助解决刑事案件。其中，基质辅助激光解吸/电离质谱（MALDI MS），特别是 MALDI MS 成像（MALDI MSI），在法医应用中显示出了很大的潜力。由于其高度特异性，MALDI MSI 可以在无需广泛样品制备的情况下分析复杂样品中的各种化合物，提供给定分析物的化学特征和空间分布。本综述向法医科学家介绍了 MALDI MS（I），重点介绍了其基本原理以及 MALDI MS（I）在分析指纹、滥用药物及其代谢物在头发、药物样本、动物组织和文件墨迹中的应用。
