Mahmoud Saad, Beauchesne Luc M, Davis Darryl R, Glover Christopher
Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada.
Can J Cardiol. 2007 May 1;23(6):475-7. doi: 10.1016/s0828-282x(07)70787-0.
Chronic excess alcohol use is a well-established cause of dilated cardiomyopathy. The clinical features are variable because patients may be asymptomatic despite there being evidence of severe left ventricular dysfunction. Although the mechanism of alcohol-induced cardiomyopathy is not clearly understood, abstinence from alcohol has been associated with improvement in left ventricular function. Conversely, patients with ongoing alcohol abuse and dilated cardiomyopathy have a poor prognosis, with progressive biventricular failure and, ultimately, death. A case of rapid reversal of alcohol-induced cardiomyopathy with abstinence is reviewed. The present case highlights the acute toxic nature of alcohol and the potential for rapid functional recovery.
长期过量饮酒是扩张型心肌病的一个公认病因。其临床特征多变,因为尽管有严重左心室功能障碍的证据,但患者可能无症状。虽然酒精性心肌病的机制尚不清楚,但戒酒与左心室功能改善有关。相反,持续酗酒且患有扩张型心肌病的患者预后较差,会出现进行性双心室衰竭,最终导致死亡。本文回顾了一例因戒酒使酒精性心肌病迅速逆转的病例。该病例凸显了酒精的急性毒性以及功能快速恢复的可能性。