Bazzichi Laura, Rossi Alessandra, Giuliano Tiziana, De Feo Francesca, Giacomelli Camillo, Consensi Arianna, Ciapparelli Antonio, Consoli Giorgio, Dell'Osso Liliana, Bombardieri Stefano
Division of Rheumatology, Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy.
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy.
Clin Rheumatol. 2007 Dec;26(12):2115-2120. doi: 10.1007/s10067-007-0636-8. Epub 2007 May 9.
Our objectives were to investigate thyroid abnormalities and autoimmunity in 120 patients affected by fibromyalgia (FM) and to study their relationships with clinical data and symptoms. Thyroid assessment by means of antithyroglobulin antibodies, antithyroid peroxidase antibodies, free triiodo-thyronine, free thyroxine, and thyroid stimulating hormone analyses was carried out. The clinical parameters "Fibromyalgia Impact Questionnaire", pain, tender points, fatigue, and other symptoms, and the presence of depression or anxiety disorders were evaluated. The basal thyroid hormone levels of FM patients were in the normal range, while 41% of the patients had at least one thyroid antibody. Patients with thyroid autoimmunity showed a higher percentage of dry eyes, burning, or pain with urination, allodynia, blurred vision, and sore throat. Correlations found between thyroid autoimmunity and age or with the presence of depression or anxiety disorders were not significant. However, in the cohort of post-menopausal patients, the frequency of thyroid autoimmunity was higher with respect to pre-menopausal patients. In conclusion, autoimmune thyroiditis is present in an elevated percentage of FM patients, and it has been associated with the presence of typical symptoms of the disease.
我们的目标是调查120例纤维肌痛（FM）患者的甲状腺异常和自身免疫情况，并研究它们与临床数据及症状之间的关系。通过抗甲状腺球蛋白抗体、抗甲状腺过氧化物酶抗体、游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素分析进行甲状腺评估。对“纤维肌痛影响问卷”、疼痛、压痛点、疲劳及其他症状等临床参数，以及抑郁或焦虑症的存在情况进行了评估。FM患者的基础甲状腺激素水平在正常范围内，而41%的患者至少有一种甲状腺抗体。患有甲状腺自身免疫的患者出现干眼、灼烧感或尿痛、痛觉过敏、视力模糊和喉咙痛的比例更高。甲状腺自身免疫与年龄或抑郁或焦虑症的存在之间的相关性不显著。然而，在绝经后患者队列中，甲状腺自身免疫的发生率高于绝经前患者。总之，FM患者中自身免疫性甲状腺炎的发生率较高，且与该病的典型症状有关。
