Faculty of Health and Sport Sciences, University of Zaragoza, 22002 Huesca, Spain.
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK.
Int J Environ Res Public Health. 2023 Jan 27;20(3):2261. doi: 10.3390/ijerph20032261.
Downgrade alterations in the growth hormone (GH) might be involved in the development of some of the fibromyalgia syndrome (FMS) symptoms. Our aim was to assess the effects of an aerobic exercise programme on the GH levels in patients with FMS. A randomised controlled trial was developed. Sixty-four Spanish women with FMS were randomly assigned to the experimental arm (n = 33) and treated with a 16-week group physical exercise programme based on low impact aerobic dance (three weekly sessions, one-hour each), or to the treatment-as-usual (TAU) control arm (n = 31). The primary outcome was the GH response to acute exercise. Secondary outcomes were GH basal, sensitivity to pain, body composition, aerobic capacity, and quality of life. The ANCOVA results showed a moderate effect of treatment improving the GH response to acute exercise. Other effects were substantial for aerobic capacity, quality of life, and body composition. Pre-intervention GH response to acute exercise was related to improvements in aerobic capacity and quality of life. An aerobic exercise programme may improve the response of the GH, aerobic capacity, body composition, and quality of life in women with FMS. The normalization of neuro-hormonal patterns involving the GH might be key for improving some FMS symptoms.
生长激素（GH）水平降低可能与纤维肌痛综合征（FMS）的一些症状的发展有关。我们的目的是评估有氧运动方案对 FMS 患者 GH 水平的影响。开展了一项随机对照试验。64 名患有 FMS 的西班牙女性被随机分配到实验组（n = 33），接受为期 16 周的团体有氧运动方案，该方案基于低冲击有氧舞蹈（每周三次，每次一小时），或治疗常规（TAU）对照组（n = 31）。主要结果是 GH 对急性运动的反应。次要结果是 GH 基础值、对疼痛的敏感性、身体成分、有氧能力和生活质量。ANCOVA 结果显示，治疗有适度影响，可改善 GH 对急性运动的反应。其他效果在有氧能力、生活质量和身体成分方面也非常显著。急性运动时 GH 反应的预先干预与有氧能力和生活质量的改善有关。有氧运动方案可能会改善 FMS 女性的 GH 反应、有氧能力、身体成分和生活质量。涉及 GH 的神经激素模式的正常化可能是改善某些 FMS 症状的关键。
