Herath Wimal, Ferreira Daneel, Khan Ikhlas A
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Nat Prod Res. 2007 May;21(5):444-50. doi: 10.1080/14786410601082144.
Microbial metabolism of the cancer chemopreventive agent, curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione] (1) with Pichia anomala (ATCC 20170) yielded four major metabolites, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (2), 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)heptan-3-one (3), 1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3,5-diol (4), 5-hydroxy-1,7-bis(4-hydroxyphenyl)heptane-3-one (5) and two minor products, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)heptane-3,5-diol (6) and 1,7-bis(4-hydroxyphenyl)heptane-3,5-diol (7). The structures of compounds 2-5 were established on the basis of spectroscopic data. Compounds 6 and 7 were assigned tentative structures.
癌症化学预防剂姜黄素[（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）庚-1,6-二烯-3,5-二酮]（1）与异常毕赤酵母（ATCC 20170）的微生物代谢产生了四种主要代谢物，5-羟基-1,7-双（4-羟基-3-甲氧基苯基）庚-3-酮（2）、5-羟基-7-（4-羟基-3-甲氧基苯基）-1-（4-羟基苯基）庚-3-酮（3）、1,7-双（4-羟基-3-甲氧基苯基）庚-3,5-二醇（4）、5-羟基-1,7-双（4-羟基苯基）庚烷-3-酮（5）以及两种次要产物，1-（4-羟基-3-甲氧基苯基）-7-（4-羟基苯基）庚烷-3,5-二醇（6）和1,7-双（4-羟基苯基）庚烷-3,5-二醇（7）。化合物2-5的结构根据光谱数据确定。化合物6和7被赋予暂定结构。
