从毛果枳椇树皮中分离得到对映体1,2-双(4-羟基-3-甲氧基苯基)-1,3-丙二醇1-O-葡萄糖苷及其绝对构型

Isolation and absolute structures of enantiomeric 1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol 1-O-glucosides from the bark of Hovenia trichocarpa.

作者信息

Yoshikawa K, Mimura N, Arihara S

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.

出版信息

J Nat Prod. 1998 Sep;61(9):1137-9. doi: 10.1021/np980003d.

DOI:10.1021/np980003d

PMID:9748383

Abstract

Two 1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol 1-O-glucosides, hovetrichosides A (1) and B (2), were isolated from the bark of Hovenia trichocarpa. Their structures were established by extensive NMR experiments and chemical methods. Compounds 1 and 2 were (1R), (2S)-1-(4-hydroxy-3-methoxyphenyl)-2-(4-hydroxy-3-methoxyphenyl)-1, 3-propanediol 1-O-beta-D-glucopyranoside and (1S), (2R)-1-(4-hydroxy-3-methoxyphenyl)-2-(4-hydroxy-3-methoxyphenyl)-1, 3-propanediol 1-O-beta-D-glucopyranoside, respectively.

摘要

从毛果枳椇树皮中分离得到了两种1,2 - 双（4 - 羟基 - 3 - 甲氧基苯基）-1,3 - 丙二醇1 - O - 葡萄糖苷，即枳椇苷A（1）和枳椇苷B（2）。通过广泛的核磁共振实验和化学方法确定了它们的结构。化合物1和2分别为(1R),(2S)-1-(4 - 羟基 - 3 - 甲氧基苯基)-2-(4 - 羟基 - 3 - 甲氧基苯基)-1,3 - 丙二醇1 - O - β - D - 吡喃葡萄糖苷和(1S),(2R)-1-(4 - 羟基 - 3 - 甲氧基苯基)-2-(4 - 羟基 - 3 - 甲氧基苯基)-1,3 - 丙二醇1 - O - β - D - 吡喃葡萄糖苷。