Shen Liang, Liu Lu, Ji Hong-Fang
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, PR China.
Food Nutr Res. 2017 Aug 9;61(1):1361780. doi: 10.1080/16546628.2017.1361780. eCollection 2017.
Curcumin, the major active component of turmeric (), is widely used as a spice and food-coloring agent, and also exhibits multiple biological activities. However, as curcumin has poor systemic bioavailability its pharmacology remains to be elucidated. Owing to the high concentration of curcumin in the gastrointestinal tract after oral administration, we hypothesize that it may exert regulative effects on the gut microbiota. We investigated the regulative effects of oral curcumin administration on the gut microbiota of C57BL/6 mice and found that curcumin significantly affected the abundance of several representative families in gut microbial communities, including Prevotellaceae, Bacteroidaceae, and Rikenellaceae. Considering the pathogenic associations between gut microbiota and many diseases, the present findings may help us to interpret the therapeutic benefits of curcumin.
姜黄素是姜黄的主要活性成分，被广泛用作香料和食品着色剂，还具有多种生物活性。然而，由于姜黄素的全身生物利用度较差，其药理学机制仍有待阐明。口服给药后，胃肠道中姜黄素浓度较高，因此我们推测它可能对肠道微生物群产生调节作用。我们研究了口服姜黄素对C57BL/6小鼠肠道微生物群的调节作用，发现姜黄素显著影响肠道微生物群落中几个代表性菌科的丰度，包括普雷沃氏菌科、拟杆菌科和理研菌科。鉴于肠道微生物群与许多疾病之间的致病关系,目前的研究结果可能有助于我们理解姜黄素的治疗益处。
