心脏手术中的长链五聚体蛋白3：“体外循环”和“非体外循环”患者的不同反应
The long pentraxin 3 in cardiac surgery: distinct responses in "on-pump" and "off-pump" patients.
作者信息
Kunes Pavel, Lonsky Vladimir, Mandak Jiri, Kolackova Martina, Andrys Ctirad, Kudlova Manuela, Krejsek Jan
机构信息
Department of Cardiac Surgery, Charles University in Prague, University Hospital and Faculty of Medicine in Hradec Králové, Czech Republic.
出版信息
Scand Cardiovasc J. 2007 Jun;41(3):171-9. doi: 10.1080/14017430701324262.
OBJECTIVE
Pentraxin 3 (PTX3) is a newly identified acute phase reactant with non-redundant functions in innate immunity. The purpose of this study was to assess the kinetics of release of PTX3 in cardiac surgical patients, operated on either with or without the use of cardiopulmonary bypass (CPB).
DESIGN
Thirty-four patients, seventeen in each group, were randomly assigned to CABG surgery performed either with ("on-pump") or without ("off-pump") CPB. Blood samples were collected both during and after the operation up to the 7(th) day.
RESULTS
In patients operated on with the use of CPB, PTX3 levels increased throughout the operation. Compared to baseline levels the highest PTX3 value (p<0.000) was attained on the 1(st) postoperative day in both "on-pump" and "off-pump" patients. In contrast to CPB patients, however, PTX3 levels in the latter group declined slowly, remaining elevated as long as the 3(rd) postoperative day (p<0.042).
CONCLUSIONS
Operations performed with the use of CPB are associated with a more pronounced release of PTX3 immediately after operation.
目的
pentraxin 3（PTX3）是一种新发现的急性期反应物，在先天免疫中具有非冗余功能。本研究的目的是评估在使用或不使用体外循环（CPB）进行心脏手术的患者中PTX3的释放动力学。
设计
34例患者，每组17例，随机分配接受使用CPB（“体外循环”）或不使用CPB（“非体外循环”）进行的冠状动脉旁路移植术（CABG）。在手术期间和术后直至第7天采集血样。
结果
在使用CPB进行手术的患者中，PTX3水平在整个手术过程中均升高。与基线水平相比，“体外循环”和“非体外循环”患者术后第1天达到最高PTX3值（p<0.000）。然而，与CPB患者相反，后一组中的PTX3水平下降缓慢，直到术后第3天仍保持升高（p<0.042）。
结论
使用CPB进行的手术与术后立即更明显的PTX3释放有关。
Zotero 插件