Hopper Kelly J, Cray Carolyn
Division Of Veterinary Resources, Miller School of Medicine, University of Miami, Miami, FL, USA.
J Am Assoc Lab Anim Sci. 2007 May;46(3):53-7.
The aim of this study was to evaluate the clinical performance of a portable analyzer for use in cynomolgus monkeys (Macaca fasicularis). During semiannual health screening, blood samples from 23 animals were analyzed by both the portable clinical analyzer and the institutional comparative pathology laboratory. Portable clinical analyzers have been evaluated for use in other species, but the suitability for macaques has not yet been determined. Results for glucose, urea (BUN), sodium, potassium, chloride, hematocrit, hemoglobin, and total CO2 were compared by overall t test, paired t test, and Pearson correlation. Only glucose and BUN did not differ in the overall t test between methods. Only potassium values did not differ in the paired t test. Compared with those from the portable analyzer, laboratory values were lower for glucose, hematocrit, hemoglobin, and total CO2 and higher for electrolytes and BUN. All values were within normal ranges for cynomolgus macaques which, in this study, were all apparently healthy, physiologically normal animals. We attributed differences between methods to sample type and handling and the physiologic changes in blood after collection. These results indicate that direct comparison of values obtained through different methods may not be valid, and normal ranges for point-of-care devices should be developed for each species.
本研究的目的是评估一种用于食蟹猴（猕猴）的便携式分析仪的临床性能。在半年一次的健康筛查期间，便携式临床分析仪和机构比较病理学实验室对23只动物的血样进行了分析。便携式临床分析仪已在其他物种中进行了评估，但对猕猴的适用性尚未确定。通过总体t检验、配对t检验和Pearson相关性比较了葡萄糖、尿素（BUN）、钠、钾、氯、血细胞比容、血红蛋白和总二氧化碳的结果。在总体t检验中，只有葡萄糖和BUN在两种方法之间没有差异。在配对t检验中，只有钾值没有差异。与便携式分析仪的结果相比，实验室检测的葡萄糖、血细胞比容、血红蛋白和总二氧化碳值较低，电解质和BUN值较高。所有值均在食蟹猴的正常范围内，在本研究中，这些食蟹猴显然都是健康、生理正常的动物。我们将方法之间的差异归因于样本类型和处理方式以及采血后血液中的生理变化。这些结果表明，通过不同方法获得的值进行直接比较可能无效，应针对每个物种制定即时检测设备的正常范围。
