Morra Marco
Nobil Bio Ricerche srl, Strada San Rocco 36, 14018 Villafranca d'Asti, Italy.
Expert Rev Med Devices. 2007 May;4(3):361-72. doi: 10.1586/17434440.4.3.361.
In this review, surface modification of implant devices by immobilization of biological molecules is discussed. A brief introduction to the development of biomolecular surface science is presented, followed by a review of current activities in selected fields. Bone-contacting devices and some cardiovascular implant devices are reviewed as paradigmatic examples of research that is currently taking place. Advances in the basic fields of cell and tissue biology, in addition to concurrent developments in surface science tools, suggest that 'peri-implant biologics', or the control and direction of the host response at the implant-tissue interface by implant-surface-linked biomolecules, could be a major area of growth in the medical devices field in the next few years.
在本综述中，讨论了通过固定生物分子对植入装置进行表面改性。简要介绍了生物分子表面科学的发展，随后综述了选定领域的当前研究活动。作为当前正在进行的研究的典型例子，对骨接触装置和一些心血管植入装置进行了综述。细胞和组织生物学基础领域的进展，以及表面科学工具的同步发展，表明“植入物周围生物学”，即通过植入物表面连接的生物分子控制和引导植入物-组织界面处的宿主反应，可能是未来几年医疗器械领域的一个主要增长领域。
