Cascella Nicola G, Takaki Manabu, Lin Sandra, Sawa Akira
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
J Neurochem. 2007 Aug;102(3):587-94. doi: 10.1111/j.1471-4159.2007.04628.x.
It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.
有人提出，神经发育过程中的紊乱可能在精神分裂症（SZ）的病因学中起关键作用。脑成像、流行病学和病理学研究以及对似乎与中枢神经系统发育有关的SZ易感基因的发现都支持了这一前提。在此，我们讨论了当前用于研究SZ神经发育影响的方法和模型的局限性。我们赞同以下提议：嗅觉上皮在整个生命过程中持续进行神经发育，它可能是理解该疾病病理生理学的另一种模型。
