多柔比星负载红细胞治疗的淋巴瘤患者的多柔比星药代动力学。
Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes.
作者信息
Skorokhod Oleksii, Kulikova Elena V, Galkina Ninel M, Medvedev Pavel V, Zybunova Elena E, Vitvitsky Victor M, Pivnik Aleksandr V, Ataullakhanov Fazoil I
出版信息
Haematologica. 2007 Apr;92(4):570-1. doi: 10.3324/haematol.10770.
PMID:17488674
Abstract
Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.
摘要
给15名淋巴瘤患者输注了载有多柔比星的红细胞（DLE）。与标准多柔比星给药相比，血液中抗生素的峰值浓度降低了55%，多柔比星的循环时间延长了数倍，浓度-时间曲线下面积增加了5倍。患者对DLE耐受性良好。
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