Xu Peipei, Wang Ruju, Wang Xiaohui, Ouyang Jian
Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People's Republic of China.
Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People's Republic of China; Medical School, Southeast University, Nanjing, People's Republic of China.
Onco Targets Ther. 2016 May 17;9:2873-84. doi: 10.2147/OTT.S104691. eCollection 2016.
In the past few years, nanomaterial-based drug delivery systems have been applied to enhance the efficacy of therapeutics and to alleviate negative effects through the controlled delivery of targeting and releasing agents. However, few drug carriers can achieve high targeting efficacy, even when targeting modalities and surface markers are introduced. Immunological problems have also limited their wide applications. Biological drug delivery systems, such as erythrocytes, platelets, and albumin, have been extensively investigated because of their unique properties. In this review, erythrocytes, platelets, and albumin are described as efficient drug delivery systems. Their properties, applications, advantages, and limitations in disease treatment are explained. This review confirms that these systems can be used to facilitate a specific, biocompatible, and smart drug delivery.
在过去几年中，基于纳米材料的药物递送系统已被应用于通过靶向和释放剂的可控递送提高治疗效果并减轻负面影响。然而，即使引入了靶向方式和表面标志物，也很少有药物载体能够实现高靶向效率。免疫问题也限制了它们的广泛应用。生物药物递送系统，如红细胞、血小板和白蛋白，因其独特的性质而受到广泛研究。在本综述中，红细胞、血小板和白蛋白被描述为高效的药物递送系统。解释了它们在疾病治疗中的性质、应用、优点和局限性。本综述证实，这些系统可用于促进特定的、生物相容的和智能的药物递送。
