Lecompte Thomas, Wahl Denis, Perret-Guillaume Christine, Hemker H Coenraad, Lacolley Patrick, Regnault Véronique
Haematologica. 2007 May;92(5):714-5. doi: 10.3324/haematol.10577.
Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.
利用血栓形成描记法对40例抗磷脂抗体（aPL）患者（24例有血栓形成）进行了抗磷脂抗体对凝血干扰的研究。活化蛋白C抗凝途径的损害被真正的抗凝作用部分抵消。最终结果是促凝表型，这与aPL患者血栓形成风险增加7倍相关。
