Cottrell Gilles, Mary Jean-Yves, Barro Drissa, Cot Michel
Institut de Recherche pour le Développement, Paris, France.
Am J Trop Med Hyg. 2007 May;76(5):849-54.
Malaria in pregnant women is related to low birth weight (LBW), a factor contributing to infant mortality. Which period of infection during pregnancy leads to the most harmful consequences is unclear. We analyzed data collected in Burkina Faso for 1190 pregnant women. Birth weight was analyzed through multivariate linear and logistic regressions. Infection after 6 months of pregnancy was related to a decrease in mean birth weight (-105 g, P = 0.02) and a higher risk of low birth weight (AOR = 1.8, P = 0.02). A trend was found between infection before 4 months of pregnancy and a decrease in birth weight (-68 g, P = 0.08). This suggests that the end of pregnancy is the most important period in terms of public health, but infection at the beginning of pregnancy may also have consequences. Malaria prevention policies should be started early in pregnancy, especially by implementing the systematic use of insecticide-treated nets.
孕妇疟疾与低出生体重有关，低出生体重是导致婴儿死亡的一个因素。孕期哪个感染阶段会导致最有害的后果尚不清楚。我们分析了在布基纳法索收集的1190名孕妇的数据。通过多变量线性回归和逻辑回归分析出生体重。妊娠6个月后感染与平均出生体重下降（-105克，P = 0.02）和低出生体重风险较高（调整后的比值比=1.8，P = 0.02）有关。在妊娠4个月前感染与出生体重下降（-68克，P = 0.08）之间发现了一种趋势。这表明就公共卫生而言，妊娠晚期是最重要的时期，但妊娠初期感染也可能产生后果。疟疾预防政策应在孕期早期启动，特别是通过实施系统使用经杀虫剂处理的蚊帐。
