Cottrell Gilles, Mary Jean-Yves, Barro Drissa, Cot Michel
Institut de Recherche pour le Développement, UR 010 Santé de la Mère et de l'Enfant en Milieu Tropical, Paris, France.
Am J Trop Med Hyg. 2005 Dec;73(6):1112-8.
Placental infection measured by placental smear at delivery is a standard indicator, widely used to characterize malaria infection in pregnant women. However, a single measure can hardly reflect the entire history of infection during pregnancy. To investigate the relation between this indicator and peripheral infection during pregnancy, we used data collected in a randomized trial of malaria prophylaxis in 928 pregnant women in Burkina Faso, 1987-1988, during which repeated measures of peripheral infection were taken. We analyzed placental infection using a logistic model, with two methods for handling missing data. Peripheral infection during two periods of pregnancy was significantly related to placental infection at delivery, before the fifth month: OR = 2.9 [1.3; 6.3]; after 7 months: OR = 4.9 [2.7; 8.8]). Therefore, an early peripheral infection may persist throughout gestation, and placental infection is a good indicator of the women's parasitological status during pregnancy.
分娩时通过胎盘涂片测量的胎盘感染是一项标准指标，广泛用于表征孕妇的疟疾感染情况。然而，单一指标很难反映孕期感染的整个历程。为研究该指标与孕期外周感染之间的关系，我们使用了1987 - 1988年在布基纳法索对928名孕妇进行的疟疾预防随机试验中收集的数据，在此期间对外周感染进行了多次测量。我们使用逻辑模型分析胎盘感染情况，采用两种方法处理缺失数据。孕期两个阶段的外周感染与分娩时的胎盘感染显著相关，在第五个月之前：比值比（OR）= 2.9 [1.3；6.3]；7个月之后：OR = 4.9 [2.7；8.8]）。因此，早期外周感染可能会持续整个妊娠期，胎盘感染是孕期女性寄生虫学状态的良好指标。
