Aoyama Hajime, Hirata Tetsuo, Sakugawa Hiroshi, Watanabe Takako, Miyagi Satoru, Maeshiro Tatsuji, Chinen Takayuki, Kawane Mariko, Zaha Osamu, Nakayoshi Tomokuni, Kinjo Fukunori, Fujita Jiro
Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Am J Trop Med Hyg. 2007 May;76(5):972-6.
A case-control study was undertaken to describe the prevalence of Strongyloides stercoralis infection among patients with autoimmune liver diseases, such as primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC). This study covered 4,117 patients who were admitted to hospitals in Okinawa, Japan, between 1988 and 2006. During this period, 538 patients had the following chronic liver diseases: PBC, AIH, PSC, chronic viral hepatitis group, and alcoholic liver disease. The other 3,579 patients who were hospitalized and underwent parasitologic tests served as controls. The frequency of S. stercoralis infection in the autoimmune liver diseases group (1.0%) was lower than that found in the control group (7.0%; P = 0.0063). None of the female patients with PBC born before 1955 had S. stercoralis infection, which was also statistically significant (P = 0.045). We hypothesized that immunomodulation by S. stercoralis infection may lower the incidence of autoimmune liver disease.
开展了一项病例对照研究，以描述粪类圆线虫感染在自身免疫性肝病患者中的流行情况，这些自身免疫性肝病包括原发性胆汁性肝硬化（PBC）、自身免疫性肝炎（AIH）和原发性硬化性胆管炎（PSC）。本研究涵盖了1988年至2006年间在日本冲绳住院的4117名患者。在此期间，538名患者患有以下慢性肝病：PBC、AIH、PSC、慢性病毒性肝炎组和酒精性肝病。另外3579名住院并接受寄生虫学检测的患者作为对照。自身免疫性肝病组粪类圆线虫感染率（1.0%）低于对照组（7.0%；P = 0.0063）。1955年以前出生的PBC女性患者均无粪类圆线虫感染，这也具有统计学意义（P = 0.045）。我们推测，粪类圆线虫感染引起的免疫调节可能会降低自身免疫性肝病的发病率。
