Machado Eleuza R, Teixeira Eliane M, Gonçalves-Pires Maria Do Rosario F, Loureiro Zaira M, Araújo Rogério A, Costa-Cruz Julia M
Laboratório de Parasitologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlindia - Minas Gerais, Brazil.
Scand J Infect Dis. 2008;40(2):154-8. doi: 10.1080/00365540701558730.
This study examined the frequency of Strongyloides stercoralis infection in patients with gastrointestinal cancer through parasitological and immunological tests. A total of 77 patients were evaluated, 33 with gastrointestinal cancer and 44 controls with other types of cancers. All the patients were undergoing chemotherapy and 14 (18.2%) were receiving concomitant radiotherapy. For a parasitological diagnosis, we applied the Baermann and Lutz methods. The immunological diagnosis involved the indirect fluorescence antibody test (IFAT) and enzyme linked immunosorbent assay (ELISA) to detect IgG antibodies using Strongyloides ratti antigens. The frequency of positive S. stercoralis in gastrointestinal cancer diagnosed by parasitological methods was 3 cases (9.1%), by serology it was 8 cases (24.2%). In the control group 1 case (2.3%) of S. stercoralis was diagnosed by parasitological methods and 2 cases (4.5%) by immunological tests (p<0.05). Patients with gastrointestinal cancer had a 6.7-fold greater chance of testing positive for S. stercoralis infection. Our data highlight the importance of parasitological and immunological diagnosis for S. stercoralis in patients with gastrointestinal cancer living in endemic areas of strongyloidiasis, since they have a higher risk of becoming infected with S. stercoralis than patients with other types of cancer.
本研究通过寄生虫学和免疫学检测，调查了胃肠癌患者中粪类圆线虫感染的频率。共评估了77例患者，其中33例为胃肠癌患者，44例为其他类型癌症的对照者。所有患者均在接受化疗，14例（18.2%）同时接受放疗。对于寄生虫学诊断，我们采用了贝尔曼法和卢茨法。免疫学诊断包括间接荧光抗体试验（IFAT）和酶联免疫吸附测定（ELISA），使用大鼠粪类圆线虫抗原检测IgG抗体。通过寄生虫学方法诊断的胃肠癌患者中粪类圆线虫阳性率为3例（9.1%），血清学诊断为8例（24.2%）。在对照组中，通过寄生虫学方法诊断出1例（2.3%）粪类圆线虫，通过免疫学检测诊断出2例（4.5%）（p<0.05）。胃肠癌患者粪类圆线虫感染检测呈阳性的几率高出6.7倍。我们的数据突出了在粪类圆线虫病流行地区的胃肠癌患者中，对粪类圆线虫进行寄生虫学和免疫学诊断的重要性，因为他们比其他类型癌症患者感染粪类圆线虫的风险更高。
