Extermann Martine, Hurria Arti
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA.
J Clin Oncol. 2007 May 10;25(14):1824-31. doi: 10.1200/JCO.2007.10.6559.
During the last decade, oncologists and geriatricians have begun to work together to integrate the principles of geriatrics into oncology care. The increasing use of a comprehensive geriatric assessment (CGA) is one example of this effort. A CGA includes an evaluation of an older individual's functional status, comorbid medical conditions, cognition, nutritional status, psychological state, and social support; and a review of the patient's medications. This article discusses recent advances on the use of a CGA in older patients with cancer.
In this article, we provide an update on the studies that address the domains of a geriatric assessment applied to the oncology patient, review the results of the first studies evaluating the use of a CGA in developing interventions to improve the care of older adults with cancer, and discuss future research directions.
The evidence from recent studies demonstrates that a CGA can predict morbidity and mortality in older patients with cancer. Accumulating data show the benefits of incorporating a CGA in the evaluation of older patients with cancer. Prospective trials evaluating the utility of a CGA to guide interventions to improve the quality of cancer care in older adults are justified.
Growing evidence demonstrates that the variables examined in a CGA can predict morbidity and mortality in older patients with cancer, and uncover problems relevant to cancer care that would otherwise go unrecognized.
在过去十年中，肿瘤学家和老年病学家开始共同努力，将老年医学原则融入肿瘤护理中。越来越多地使用综合老年评估（CGA）就是这一努力的一个例子。CGA包括对老年人的功能状态、合并症、认知、营养状况、心理状态和社会支持进行评估；以及审查患者的用药情况。本文讨论了在老年癌症患者中使用CGA的最新进展。
在本文中，我们提供了有关针对肿瘤患者应用老年评估领域的研究的最新情况，回顾了首批评估使用CGA制定干预措施以改善老年癌症患者护理的研究结果，并讨论了未来的研究方向。
近期研究的证据表明，CGA可以预测老年癌症患者的发病率和死亡率。越来越多的数据显示了在评估老年癌症患者时纳入CGA的益处。进行前瞻性试验以评估CGA在指导干预措施以改善老年癌症患者癌症护理质量方面的效用是合理的。
越来越多的证据表明，CGA中所检查的变量可以预测老年癌症患者的发病率和死亡率，并发现与癌症护理相关的、否则会未被识别的问题。
