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虚弱与哮喘的关联。

Association between Frailty and Asthma.

机构信息

Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Busan 49241, Republic of Korea.

Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.

出版信息

Medicina (Kaunas). 2024 Sep 10;60(9):1479. doi: 10.3390/medicina60091479.

DOI:10.3390/medicina60091479
PMID:39336520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11434337/
Abstract

: This study investigated whether there is an association between elderly frailty and asthma. : We examined 9745 elderly participants who did not have asthma and 275 elderly patients who had asthma diagnosed by a doctor from the 2020 Survey of Living Conditions and Welfare Needs of Korean Older Persons Survey. Study Selections: The Korean version of the fatigue, resistance, ambulation, illnesses, and loss of weight (K-FRAIL) scale was used to determine their level of frailty. The relationship between frailty and geriatric asthma was examined using multiple logistic regression analysis, which was adjusted for a number of confounding variables (socioeconomic, health behavior, psychological characteristics, and functional status). : Frailty as defined by the K-FRAIL scale was significantly higher in the asthma group (7.6%) than the non-asthma group (4.9%). The frailty phenotype component showed that resistance, ambulation, and illness severity were more severe in the asthma group than the non-asthma group. After adjusting, asthma was significantly associated with an increased risk of frailty (OR 1.45; 95% confidence interval [CI] 1.01-2.09) compared to the non-asthma group. : Frailty might be associated with elderly asthma in patients from the Korean population. Frailty may not only be associated with asthma, but also with other diseases. So, more evidence is needed to establish this association.

摘要

: 本研究旨在探讨老年人衰弱与哮喘之间是否存在关联。: 我们检查了 9745 名没有哮喘的老年人和 275 名由医生诊断为哮喘的老年人,这些老年人来自 2020 年韩国老年人生活状况和福利需求调查。研究选择:使用疲劳、抵抗力、活动能力、疾病和体重减轻(K-FRAIL)量表的韩语版本来确定他们的衰弱程度。使用多变量逻辑回归分析检查衰弱与老年哮喘之间的关系,该分析调整了许多混杂变量(社会经济、健康行为、心理特征和功能状态)。: 根据 K-FRAIL 量表,哮喘组的衰弱程度(7.6%)明显高于非哮喘组(4.9%)。衰弱表型成分表明,与非哮喘组相比,哮喘组的抵抗力、活动能力和疾病严重程度更严重。调整后,与非哮喘组相比,哮喘与衰弱风险增加显著相关(OR 1.45;95%置信区间 [CI] 1.01-2.09)。: 在韩国人群中,衰弱可能与老年哮喘有关。衰弱不仅与哮喘有关,还可能与其他疾病有关。因此,需要更多的证据来建立这种关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/11434337/679feea8cd01/medicina-60-01479-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/11434337/679feea8cd01/medicina-60-01479-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/11434337/679feea8cd01/medicina-60-01479-g001.jpg

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The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study.患支气管哮喘风险与身体虚弱之间的因果关系:一项双向两样本孟德尔随机化研究。
Front Med (Lausanne). 2023 Dec 15;10:1289026. doi: 10.3389/fmed.2023.1289026. eCollection 2023.
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Frailty Prevalence and Association with Clinical Outcomes in Interstitial Lung Disease, Asthma, and Pleural Disease.间质性肺疾病、哮喘和胸膜疾病中的衰弱患病率及其与临床结局的关联
Geriatrics (Basel). 2023 Aug 13;8(4):82. doi: 10.3390/geriatrics8040082.
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Handgrip strength as a diagnostic tool for frailty risk in elderly patients with moderate to severe asthma.
握力作为一种诊断工具,可用于评估中重度哮喘老年患者的虚弱风险。
J Bras Pneumol. 2023 Jul 24;49(3):e20220465. doi: 10.36416/1806-3756/e20220465. eCollection 2023.
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Geriatrics Fact Sheet in Korea 2021.《2021年韩国老年医学概况》
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Asthma is associated with frailty among community-dwelling adults: the GAZEL cohort.哮喘与社区成年人的虚弱有关:GAZEL 队列研究。
BMJ Open Respir Res. 2020 Feb;7(1). doi: 10.1136/bmjresp-2019-000526.
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Frailty assessment in older adults with chronic obstructive respiratory diseases.老年慢性阻塞性呼吸道疾病患者的虚弱评估。
Clin Interv Aging. 2018 Aug 29;13:1513-1524. doi: 10.2147/CIA.S173239. eCollection 2018.
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The Relationship Between COPD and Frailty: A Systematic Review and Meta-Analysis of Observational Studies.COPD 与衰弱的关系:观察性研究的系统评价和荟萃分析。
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Physical activity in chronic obstructive pulmonary disease: clinical impact and risk factors.慢性阻塞性肺疾病中的体力活动:临床影响及危险因素
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