Irminger-Finger Irmgard
Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.
J Clin Oncol. 2007 May 10;25(14):1844-51. doi: 10.1200/JCO.2007.10.8928.
This review provides an overview of a selection of the most pertinent molecular pathways that link cancer and aging and focuses on those where recent advances were most important. When organizing the bulk of information on this subject, I became aware of the fact that the most evident partition, namely, mechanisms that influence aging and mechanisms that influence cancer occurrence, is difficult to apply. Most mechanisms explaining the aging process are also those that influence carcinogenesis. Mechanisms that are described in tumor suppressor pathways are also contributors to the aging process. From an intuitive point of view, there are phenomena that have traditionally been contributed to aging others to cancer-inducing factors and they are presented herein.
本综述概述了一系列将癌症与衰老联系起来的最相关分子途径，并重点关注那些近期进展最为重要的途径。在整理关于这个主题的大量信息时，我意识到一个事实，即最明显的划分，即影响衰老的机制和影响癌症发生的机制，很难应用。大多数解释衰老过程的机制也是那些影响致癌作用的机制。肿瘤抑制途径中描述的机制也是衰老过程的促成因素。从直观的角度来看，有些现象传统上被认为是导致衰老的因素，而另一些则是致癌因素，本文将对它们进行介绍。
