Zuidmeer Laurian, van Ree Ronald
Laboratory of Allergy, Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
Curr Opin Allergy Clin Immunol. 2007 Jun;7(3):269-73. doi: 10.1097/ACI.0b013e32814a5401.
To summarize recent findings on non-specific lipid transfer proteins in food allergy, with a specific focus on the localization, stability and route of sensitization.
Plant non-specific lipid transfer proteins are major food allergens, especially in the Mediterranean area. They have been identified as allergens in a number of foods and the list grows ever longer. As non-specific lipid transfer proteins are considered to be "true" food allergens that sensitize directly via the gastrointestinal tract their stability during food processing and gastric digestion has been studied in more detail. In addition, several groups have tried to determine the sensitization patterns of lipid transfer protein-reactive patients, to determine and possibly clarify the observed geographical differences in sensitization. Different sensitization routes (via the respiratory tract or even transdermally) have been suggested.
As the structure and molecular properties of non-specific lipid transfer proteins are resolved and more purified non-specific lipid transfer proteins become available for diagnostic purposes, detailed studies on the sensitization pattern and route are becoming feasible. Continuing studies on the pattern of lipid transfer protein sensitization will give more insight into the development and possible treatment of lipid transfer protein-related food allergy.
总结食物过敏中非特异性脂质转运蛋白的近期研究发现，特别关注其定位、稳定性及致敏途径。
植物非特异性脂质转运蛋白是主要的食物过敏原，在地中海地区尤为如此。它们已在多种食物中被鉴定为过敏原，且此类食物清单越来越长。由于非特异性脂质转运蛋白被认为是通过胃肠道直接致敏的“真正”食物过敏原，因此对其在食品加工和胃消化过程中的稳定性进行了更详细的研究。此外，多个研究团队试图确定脂质转运蛋白反应性患者的致敏模式，以确定并可能阐明观察到的致敏地理差异。已提出不同的致敏途径（通过呼吸道甚至经皮）。
随着非特异性脂质转运蛋白的结构和分子特性得以解析，且有更多纯化的非特异性脂质转运蛋白可用于诊断目的，关于致敏模式和途径的详细研究变得可行。对脂质转运蛋白致敏模式的持续研究将更深入地了解脂质转运蛋白相关食物过敏的发展及可能的治疗方法。
