UOSD Allergologia e Immunologia Clinica, Dip. Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Università Cattolica del Sacro Cuore, Roma, Italy.
Int J Immunopathol Pharmacol. 2020 Jan-Dec;34:2058738420974895. doi: 10.1177/2058738420974895.
Nickel (Ni), the main responsible for allergic contact dermatitis worldwide, is also involved in systemic condition called "Systemic Nickel Sulfate Allergy Syndrome (SNAS)." Likewise, IgE-mediated reactivity to Lipid Transfer Protein (LTP) represents the main cause of primary food allergy in adults of Mediterranean countries. We evaluated the prevalence of SNAS in LTP allergic patients and investigated patients' clinical features with double sensitization (LTP and Ni). A retrospective, single-center, observational study was conducted performing a complete allergological work-up including: (1) skin prick tests; (2) serum specific IgE for plant food allergens and rPru p3 (LTP); (3) patch test with 5% Ni sulfate in petrolatum. We enrolled 140 LTP allergic patients of which 36 patients (25.7% of sample) showed additional positivity to Ni patch test. Patients with double sensitization were more frequently females and reported fewer cutaneous symptoms. Higher values of sIgE for peach, apple, peanut, walnut, grain, corn, and garlic were found in LTP allergic patients, while higher values for hazelnut in the other subgroup. The prevalence of SNAS in the LTP allergic population is clinically relevant. Moreover, the clinical and immunological profiles of patients with double sensitization were different from patients monosensitized to LTP.
镍（Ni）是全球引起过敏接触性皮炎的主要原因，也与一种称为“全身性硫酸镍过敏综合征（SNAS）”的系统性疾病有关。同样，对脂质转移蛋白（LTP）的 IgE 介导的反应性是地中海国家成年人原发性食物过敏的主要原因。我们评估了 LTP 过敏患者中 SNAS 的患病率，并研究了双重致敏（LTP 和 Ni）患者的临床特征。进行了一项回顾性、单中心、观察性研究，进行了完整的过敏检查，包括：（1）皮肤点刺试验；（2）植物食物过敏原和 rPru p3（LTP）的血清特异性 IgE；（3）用 5%硫酸镍在矿脂中进行斑贴试验。我们招募了 140 名 LTP 过敏患者，其中 36 名患者（样本的 25.7%）对 Ni 斑贴试验呈额外阳性。双重致敏的患者中女性更为常见，且报告的皮肤症状较少。在 LTP 过敏患者中发现了更高的桃、苹果、花生、核桃、谷物、玉米和大蒜的 sIgE 值，而在另一亚组中榛子的 sIgE 值更高。LTP 过敏人群中 SNAS 的患病率具有临床相关性。此外，双重致敏患者的临床和免疫学特征与仅对 LTP 过敏的患者不同。
