Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich Str. 51-59, 63225, Langen, Germany.
Departments of Experimental Immunology and of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Curr Allergy Asthma Rep. 2021 Feb 3;21(2):7. doi: 10.1007/s11882-020-00982-w.
To provide an overview of the prevalence and clinical manifestation of non-specific lipid transfer proteins (LTP)-mediated allergies outside the Mediterranean area and to address potential reasons for the different geographical significance of LTP-driven allergies.
LTPs are major allergens in the Mediterranean area, which frequently can elicit severe reactions. Pru p 3 the LTP from peach is reported as genuine allergen and is considered a prototypic marker for LTP-mediated allergies. However, both food and pollen LTP allergies exist outside the Mediterranean area, but with lower clinical significance, different immunogenicity, and less clarified role. Evidence has been reported that in areas with high exposure to pollen, in particular to mugwort, pollen-derived LTPs can act as a primary sensitizer to trigger secondary food allergies. Co-sensitization to unrelated allergens might be causative for less severe reactions in response to LTPs. However, the reason for the geographical different sensitization patterns to LTPs remains unclear.
介绍非特异性脂质转移蛋白（LTP）介导的过敏在环地中海地区以外的流行情况和临床表现，并探讨 LTP 驱动的过敏在不同地区具有不同重要性的潜在原因。
LTP 是环地中海地区的主要过敏原，常可引发严重反应。桃中的 Pru p 3 LTP 被报道为真正的过敏原，被认为是 LTP 介导的过敏的典型标志物。然而，食物和花粉 LTP 过敏不仅存在于环地中海地区以外，而且临床意义较低、免疫原性不同、作用尚不清楚。有证据表明，在高花粉暴露地区，特别是蒿属花粉，花粉衍生的 LTP 可作为主要致敏原引发继发性食物过敏。对无关过敏原的共同致敏可能是导致对 LTP 反应较轻的原因。然而，导致对 LTP 产生不同地区性致敏模式的原因尚不清楚。
