Neuropathic pain: molecular complexity underlies continuing unmet medical need.

Suppr

超能文献

作者信息

Kennedy Jeffrey D

机构信息

Neuroscience Discovery, Wyeth Research, CN 8000, Princeton, New Jersey 08543-8000, USA.

出版信息

J Med Chem. 2007 May 31;50(11):2547-56. doi: 10.1021/jm061023c. Epub 2007 May 10.

DOI:10.1021/jm061023c

PMID:17489577

Abstract

摘要

相似文献

Neuropathic pain: molecular complexity underlies continuing unmet medical need.

J Med Chem. 2007 May 31;50(11):2547-56. doi: 10.1021/jm061023c. Epub 2007 May 10.

Kv7 (KCNQ) channel modulators and neuropathic pain.Kv7（KCNQ）通道调节剂与神经性疼痛。

J Med Chem. 2007 May 31;50(11):2576-82. doi: 10.1021/jm060989l. Epub 2007 May 10.

Current and emerging targets to treat neuropathic pain.治疗神经性疼痛的现有及新出现的靶点。

J Med Chem. 2007 May 31;50(11):2543-6. doi: 10.1021/jm061015w. Epub 2007 May 10.

N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief.N-甲基-D-天冬氨酸拮抗剂与神经性疼痛：寻求缓解之道。

J Med Chem. 2007 May 31;50(11):2557-62. doi: 10.1021/jm060728b. Epub 2007 May 10.

The biological role of galanin in normal and neuropathic states.甘丙肽在正常和神经病变状态下的生物学作用。

Prog Brain Res. 2000;129:219-30. doi: 10.1016/S0079-6123(00)29016-X.

The role of tetrodotoxin-resistant sodium channels in pain states: are they the next target for analgesic drugs?抗河豚毒素钠通道在疼痛状态中的作用：它们会是镇痛药的下一个靶点吗？

Curr Opin Investig Drugs. 2008 Jan;9(1):83-9.

Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity.染料木黄酮是一种来自大豆的天然植物雌激素，可缓解小鼠坐骨神经慢性缩窄损伤后的神经性疼痛：具有抗炎和抗氧化活性。

J Neurochem. 2008 Oct;107(1):230-40. doi: 10.1111/j.1471-4159.2008.05614.x. Epub 2008 Aug 8.

Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment.疼痛状态下的电压门控钠通道：在病理生理学中的作用及治疗靶点

Brain Res Rev. 2009 Apr;60(1):65-83. doi: 10.1016/j.brainresrev.2008.12.005. Epub 2008 Dec 25.

Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain.代谢型谷氨酸1受体拮抗剂治疗神经性疼痛的前景

J Med Chem. 2007 May 31;50(11):2563-8. doi: 10.1021/jm060950g. Epub 2007 May 10.

[Peripheral neuropathic pain more researched than central].[外周神经性疼痛的研究比中枢性疼痛更多]

Lakartidningen. 2008;105(39):2700-5.

引用本文的文献

and evaluation of antinociceptive activities of seed extract from the plant.以及对该植物种子提取物的镇痛活性评估。

Heliyon. 2020 May 13;6(5):e03962. doi: 10.1016/j.heliyon.2020.e03962. eCollection 2020 May.

Development and Validation of a Versatile UPLC-PDA Method for Simultaneous Determination of Paracetamol, Tizanidine, Aceclofenac, and Nimesulide in Their New Combinations.一种用于同时测定新组合中对乙酰氨基酚、替扎尼定、醋氯芬酸和尼美舒利的通用超高效液相色谱-光电二极管阵列检测法的开发与验证

J Anal Methods Chem. 2018 May 14;2018:7463914. doi: 10.1155/2018/7463914. eCollection 2018.

Neuropathic pain after brachial plexus avulsion--central and peripheral mechanisms.臂丛神经撕脱伤后的神经性疼痛——中枢和外周机制

BMC Neurol. 2015 May 4;15:73. doi: 10.1186/s12883-015-0329-x.

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.非肽类神经降压素受体配体中的酰胺连接子在2型神经降压素受体的钙信号传导中起关键作用。

Bioorg Med Chem Lett. 2015;25(10):2060-4. doi: 10.1016/j.bmcl.2015.03.083. Epub 2015 Apr 3.

Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.将穿透血脑屏障的肽与神经降压肽缀合可提供镇痛作用。

J Clin Invest. 2014 Mar;124(3):1199-213. doi: 10.1172/JCI70647. Epub 2014 Feb 17.

A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain.一种 TRPA1 拮抗剂逆转奥沙利铂诱导的神经病理性疼痛。

Sci Rep. 2013;3:2005. doi: 10.1038/srep02005.

Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats.游泳疗法可减轻慢性缩窄性神经损伤引起的大鼠机械性痛觉过敏和热痛觉过敏。

Pain Med. 2013 Apr;14(4):516-25. doi: 10.1111/pme.12057. Epub 2013 Feb 25.

ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels.ω-芋螺毒素 GVIA 类似物，能结合并抑制神经元 Ca(v)2.2 离子通道。

Mar Drugs. 2012 Oct;10(10):2349-2368. doi: 10.3390/md10102349. Epub 2012 Oct 22.

Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.外周和中枢联合给予 QX-314 和辣椒素对大鼠神经病理性疼痛的差异作用。

Anesthesiology. 2012 Aug;117(2):365-80. doi: 10.1097/ALN.0b013e318260de41.

Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?联合镇痛药在（头痛）疼痛治疗中的应用：霰弹枪方法还是精确的多靶点治疗？

BMC Neurol. 2011 Mar 31;11:43. doi: 10.1186/1471-2377-11-43.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验