Terzi M, Birinci A, Cetinkaya E, Onar M K
Department of Neurology, Ondokuz Mayis University Medical School, Kurupelt-Samsun, Turkey.
Acta Neurol Scand. 2007 May;115(5):325-30. doi: 10.1111/j.1600-0404.2007.00782.x.
Tau protein is present in the microtubules of axons. Markers of various types have been used to demonstrate multiple sclerosis (MS) activity and axonal damage. This study aimed to demonstrate the association between cerebrospinal fluid (CSF) tau protein concentrations and clinical prognosis in MS patients.
We included 45 patients that were diagnosed according to the McDonald's criteria. The control group was made up of 38 patients that had no signs or symptoms related to the primary central nervous system lesion correlated with the patient group. CSF total tau protein was measured using the ELISA method based on the sandwich method with Innogenetics Innotest hTau antigen kit in pg/ml type.
In the patient group, the mean CSF total tau protein level was 238.66 +/- 237.44, whereas it was 93.65 +/- 82.14 in the control group. The mean total tau protein was higher in the three clinical forms when compared with the control group and it was statistically significant (P<0.05).
High tau protein level may be an early marker of axonal damage and this marker may be used for monitoring axon preventing therapies in the follow-up.
tau蛋白存在于轴突的微管中。已使用各种类型的标志物来证明多发性硬化症（MS）的活动和轴突损伤。本研究旨在证明MS患者脑脊液（CSF）中tau蛋白浓度与临床预后之间的关联。
我们纳入了45例根据麦克唐纳标准诊断的患者。对照组由38例与患者组相关的原发性中枢神经系统病变无体征或症状的患者组成。使用基于夹心法的ELISA方法，采用Innogenetics Innotest hTau抗原试剂盒，以pg/ml类型测量脑脊液总tau蛋白。
患者组脑脊液总tau蛋白平均水平为238.66±237.44，而对照组为93.65±82.14。与对照组相比，三种临床形式的总tau蛋白平均水平更高，且具有统计学意义（P<0.05）。
高tau蛋白水平可能是轴突损伤的早期标志物，该标志物可用于随访中监测轴突预防治疗。
