Geisen V, Stengel C, Brem S, Müller W, Greene C, Hartmann K
Medizinischen Kleintierklinik, Ludwig Maximillians University Munich, Veterinärstrasse 13, 80539 Munich, Germany.
J Small Anim Pract. 2007 Jun;48(6):324-8. doi: 10.1111/j.1748-5827.2007.00324.x. Epub 2007 May 8.
The aim of the study was to investigate the presence of serum antibodies to different Leptospira serogroups in dogs with a clinical diagnosis of leptospirosis in southern Germany and to compare seroreactivity to different serogroups with history, clinical signs, laboratory findings and survival rate.
In this study, the data of 42 dogs with the diagnosis of leptospirosis were evaluated retrospectively. Dogs were presented to the Small Animal Medicine Teaching Hospital (Medizinische Kleintierklinik) of the Ludwig Maximilians University Munich, Germany, between 1990 to 2003.
Reactivity to the serogroup grippotyphosa (13/42) was most frequently present, followed by reactivity to the serogroup saxkoebing (10/42). There was no difference in the clinical picture and the laboratory changes between dogs whose sera were reactive to different serogroups.
Most of the dogs with leptospirosis in southern Germany had sera reacting to serogroups other than icterohaemorrhagiae and canicola, which are contained in the vaccine. Thus, currently available vaccines in Europe do not protect against the most common Leptospira organisms associated with clinical disease.
本研究旨在调查德国南部临床诊断为钩端螺旋体病的犬血清中针对不同钩端螺旋体血清群的抗体,并比较不同血清群的血清反应性与病史、临床症状、实验室检查结果及存活率之间的关系。
本研究对42例诊断为钩端螺旋体病的犬的数据进行回顾性评估。这些犬于1990年至2003年间被送至德国慕尼黑路德维希 - 马克西米利安大学小动物医学教学医院(Medizinische Kleintierklinik)。
对波摩那群(13/42)的反应最为常见,其次是对萨克森宾群(10/42)的反应。血清对不同血清群有反应的犬之间,临床症状和实验室检查变化并无差异。
德国南部大多数患钩端螺旋体病的犬血清对疫苗中所含的黄疸出血群和犬群以外的血清群有反应。因此,欧洲目前可用的疫苗不能预防与临床疾病相关的最常见钩端螺旋体菌株。