Osako M, Nishida K
Department of Sanitary Engineering, Institute of Public Health, Tokyo.
Nihon Eiseigaku Zasshi. 1991 Oct;46(4):913-21. doi: 10.1265/jjh.46.913.
The purpose of our work is to develop an estimation method for odor thresholds on the basis of physicochemical properties of odorous compounds. In this report, we examined the correlation between odor thresholds (Cth) and the saturated vapor pressures (Pvp) of various odorants. Results. 1) There were very good correlations between Pvp and k. k represents an indicator of lipid affinity. In our earlier report, k was obtained by the analysis of the gas chromatography with a column packed with a support coated by a phospholipid. Accordingly the correlations show that Pvp may be an indicator of solubility into the lipid phase. 2) It was found that correlations between Pvp and Cth were very good in several homologous series of aliphatic compounds. However ionized substances, such as acids and amines, and sulfur compounds had no good correlations. 3) In odorants having more than 3-5 carbon atoms, odor thresholds of normal types were higher than those of iso types. 4) In the series of amines, the relationship between Cth and Pvp depended upon the length and the number of alkyl chains combined with the contained nitrogen atom. 5) In the series of alcohol and aldehyde, the decrease of Cth in the rate became smaller with the decrease of Pvp.
我们工作的目的是基于有气味化合物的物理化学性质开发一种气味阈值的估算方法。在本报告中，我们研究了各种气味剂的气味阈值（Cth）与饱和蒸气压（Pvp）之间的相关性。结果如下：1）Pvp与k之间存在非常好的相关性。k代表脂质亲和力的指标。在我们早期的报告中，k是通过使用填充有涂有磷脂的载体的色谱柱进行气相色谱分析获得的。因此，这些相关性表明Pvp可能是在脂质相中的溶解度指标。2）发现在几个脂肪族化合物的同系物系列中，Pvp与Cth之间的相关性非常好。然而，离子化物质，如酸和胺以及硫化合物没有良好的相关性。3）在具有3至5个以上碳原子的气味剂中，正构类型的气味阈值高于异构类型。4）在胺系列中，Cth与Pvp之间的关系取决于与所含氮原子结合的烷基链的长度和数量。5）在醇和醛系列中，随着Pvp的降低，Cth降低的速率变小。
