Efficacy of volatile organic compounds in evoking nasal pungency and odor.

Sensory irritation (pungency) figures prominently among the symptoms associated with polluted indoor environments. In order to separate the pungent from the olfactory response, we measured nasal pungency thresholds in subjects lacking olfaction (anosmics) and odor thresholds in normal controls (normosmics) for a homologous series of ketones and for selected secondary and tertiary alcohols and acetates. As seen previously for homologous alcohols and acetates, both types of nasal thresholds decreased with increasing carbon chain length. Pungency thresholds decreased exponentially with chain length. With respect to all nonreactive chemicals studied so far, threshold nasal pungency is achieved at a fairly constant percentage of vapor saturation, irrespective of molecular size or chemical functional group. Such a relationship does not hold for odor thresholds. The outcome for pungency implies an important role for a physical, rather than chemical, interaction with nasal mucosa.