Heikkinen E R, Myllylä V V, Hokkanen E, Vapaatalo H
Eur Neurol. 1976;14(2):129-37. doi: 10.1159/000114735.
Concentration of cyclic adenosine 3',5'-monophosphate (cAMP) and activities of some enzymes were measured in cerebrospinal fluid (CSF) from 38 patients with various cerebrovascular diseases. Cerebral infarction of the carotid area (less than 14 days after the attack) revealed a significant increase in CSF cAMP level in comparison to a transient ischemic attack (TIA) and cephalagia without any pathological findings (control group). A trend towards elevated values was observed also in cerebral hemorrhage, whereas the CSF cAMP concentrations in subarachnoid hemorrhage, TIA, syncope, and cerebral infarction of at least 2 months of duration were in the range of control values. A significant rise in CSF enzyme activities was observed only in hemorrhagic disorders. Hypertensive patients with TIA showed significantly higher CSF cAMP values than normotensive ones. A similar positive correlation between blood pressure and CSF aAMP concentrations was found also in subarachnoid hemorrhage and syncope groups. On the basis of the present results it is suggested that in cerebrovascular diseases CSF cAMP concentration reflects the size and the time of the destruction of cerebral cells, and correlates with hypertension of the patient possibly indicating an increased sympathetic activity.
检测了38例患有各种脑血管疾病患者脑脊液（CSF）中环磷酸腺苷（cAMP）的浓度及某些酶的活性。与短暂性脑缺血发作（TIA）和无任何病理发现的头痛患者（对照组）相比，颈动脉区脑梗死（发作后不到14天）患者脑脊液cAMP水平显著升高。脑出血患者也观察到值有升高趋势，而蛛网膜下腔出血、TIA、晕厥以及病程至少2个月的脑梗死患者脑脊液cAMP浓度处于对照值范围内。仅在出血性疾病中观察到脑脊液酶活性显著升高。患有TIA的高血压患者脑脊液cAMP值显著高于血压正常者。在蛛网膜下腔出血组和晕厥组中也发现血压与脑脊液aAMP浓度之间存在类似的正相关。根据目前的结果，提示在脑血管疾病中，脑脊液cAMP浓度反映了脑细胞破坏的程度和时间，并与患者的高血压相关，这可能表明交感神经活动增强。
