Myllyla V V
Eur Neurol. 1976;14(6):413-25. doi: 10.1159/000114768.
Cerbrospinal fluid (CSF) cyclic adenosine-3', 5'-monophosphate (cAMP) was measured in rabbits after experimental brain injury as well as in patients with cerebral contusion and cerebral concussion. In rabbits a marked elevation lasting for two weeks was observed. From the third week onwards after the injury the CSF cAMP concentration was lower than the basal level before the injury. Dexamethasone partly inhibited the elevation. Ethanol treatment decreased the CSF cAMP values. In man, the CSF cAMP concentration was significantly higher in patients with cerebral contusion than in those with cerebral concussion. Also in the latter group the cAMP values were higher than in control patients. Due to the clear differences between the various groups, measurement of cAMP concentration in CSF might have diagnostic value in evaluation of the severity of cerebral lesion in the acute phase. Also the activities of some enzymes were measured, and the results were parallel with cAMP changes but less striking.
在实验性脑损伤后的家兔以及脑挫裂伤和脑震荡患者中，检测了脑脊液（CSF）中的环磷腺苷（cAMP）。在家兔中观察到持续两周的显著升高。损伤后第三周起，脑脊液cAMP浓度低于损伤前的基础水平。地塞米松部分抑制了这种升高。乙醇处理降低了脑脊液cAMP值。在人类中，脑挫裂伤患者脑脊液cAMP浓度显著高于脑震荡患者。后者组的cAMP值也高于对照患者。由于各组之间存在明显差异，脑脊液中cAMP浓度的测定可能对急性期脑损伤严重程度的评估具有诊断价值。还检测了一些酶的活性，结果与cAMP变化平行，但不太显著。
