Stehle G, Hinohara S, Cremer P, Feng Z, Bernhardt R, Goto Y, Seidel D, Heene D L, Schettler G
1. Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, FRG.
Klin Wochenschr. 1991 Sep 16;69(14):629-32. doi: 10.1007/BF01649422.
In Asia coronary heart disease mortality is almost 10 fold less frequent than in European countries. These findings attract interest to search for different risk factor patterns. From 1982 to 1985 epidemiologic surveys were carried out in China (n = 2047), Japan (n = 7580) and Germany (n = 6052). Healthy, male subjects, aged 30 to 59 years were enrolled. The prevalence rate of hypertension for the Germans was 20% versus 18% for the Japanese, and 11% for the Chinese. About 69% of Chinese, 55% of Japanese, and 37% of Germans were smokers. About 66% of the Germans were overweight (BMI greater than 25), 17% of the Japanese, and 11% of the Chinese. The highest risk group with cholesterol levels of greater than 300 mg/dl included no Chinese subject, 0.1% of the Japanese, but 5% of the Germans. The lipoprotein profiles among the Japanese and the Chinese collectives typically showed antiatherosclerotic characteristics, whereas most Germans exhibited profiles which support development of atherosclerosis. About 36% of the participants from Germany showed 3 or more risk factors accumulated per person (Japan and China 5%). Multifactorial risk factor reduction for Germany is recommended.
在亚洲，冠心病死亡率比欧洲国家低近10倍。这些发现引发了人们对寻找不同风险因素模式的兴趣。1982年至1985年期间，在中国（n = 2047）、日本（n = 7580）和德国（n = 6052）开展了流行病学调查。纳入了年龄在30至59岁的健康男性受试者。德国人的高血压患病率为20%，日本人为18%，中国为11%。约69%的中国人、55%的日本人以及37%的德国人吸烟。约66%的德国人超重（体重指数大于25），日本人为17%，中国为11%。胆固醇水平高于300毫克/分升的最高风险组中没有中国受试者，日本人为0.1%，但德国人为5%。日本和中国人群的脂蛋白谱通常显示出抗动脉粥样硬化特征，而大多数德国人则表现出支持动脉粥样硬化发展的谱型。约36%的德国参与者每人累积有3种或更多风险因素（日本和中国为5%）。建议德国采取多因素风险因素降低措施。
