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Prognostic implications of creatine kinase elevation after primary percutaneous coronary intervention for acute myocardial infarction.急性心肌梗死直接经皮冠状动脉介入治疗后肌酸激酶升高的预后意义
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Am J Kidney Dis. 2002 Mar;39(3):539-48. doi: 10.1053/ajkd.2002.31418.
4
QT dispersion as a predictor of long-term mortality in patients with acute myocardial infarction and clinical evidence of heart failure.QT离散度作为急性心肌梗死合并心力衰竭临床证据患者长期死亡率的预测指标。
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QT dispersion and risk factors for sudden cardiac death in patients with hypertrophic cardiomyopathy.肥厚型心肌病患者的QT离散度及心脏性猝死的危险因素
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Assessment of QT dispersion for prediction of mortality or arrhythmic events after myocardial infarction: results of a prospective, long-term follow-up study.评估QT离散度对预测心肌梗死后死亡率或心律失常事件的作用：一项前瞻性长期随访研究的结果
Circulation. 1998 Jun 30;97(25):2543-50. doi: 10.1161/01.cir.97.25.2543.
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Cellular basis for QT dispersion.QT离散度的细胞基础。
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Increased precordial QTc dispersion predicts ventricular fibrillation during acute myocardial infarction.急性心肌梗死期间，胸前导联QTc离散度增加预示着心室颤动。
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急性心肌梗死患者冠状动脉支架置入术后QT离散度与预后

QT dispersion and prognosis after coronary stent placement in acute myocardial infarction.

作者信息

Ueda Hiroyasu, Hayashi Tomoshige, Tsumura Kei, Kaitani Kazuaki, Yoshimaru Kiyomichi, Nakayama Yasunori, Yoshiyama Minoru

机构信息

Department of Cardiology, Ishikiriseiki Hospital, Osaka, Japan.

出版信息

Clin Cardiol. 2007 May;30(5):229-33. doi: 10.1002/clc.20087.

DOI:10.1002/clc.20087
PMID:17492676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6652920/
Abstract

BACKGROUND

QT dispersion is increased in acute myocardial infarction (AMI), but the relation of QT dispersion to prognosis has not yet been fully elucidated.

HYPOTHESIS

The purpose of this study is to evaluate prospectively whether QT dispersion is associated with the risk of major adverse cardiac events (MACEs) and mortality after successful coronary stenting in AMI.

METHODS

One hundred and forty-two patients with AMI and undergoing successful percutaneous coronary intervention (PCI) were enrolled in this study. Corrected QT dispersion was measured before and 24 h after PCI.

RESULTS

During a period of 4477 person-months, we confirmed 21 cases of MACE. Univariate analysis indicated that corrected QT dispersion before and 24 h after PCI, age, number of Q waves, and Killip class > or = 2 were related to MACE and mortality. By multivariate analysis, corrected QT dispersion before PCI was an independent predictor of MACE and mortality, but corrected QT dispersion at 24 h after PCI was not statistically associated with MACE and mortality. Multiple-adjusted hazard ratios for a 1 standard deviation (SD) magnitude increase in corrected QT dispersion before PCI were 2.24 (95% confidence interval, 1.36-3.68, p = 0.001) for MACE and 2.71 (95% confidence interval, 1.50-4.89, >) for mortality after adjustment for age, gender, ejection fraction, and Killip class > or = 2.

CONCLUSIONS

Corrected QT dispersion before PCI is associated with an increased risk of MACE and mortality after successful PCI in patients with AMI.

摘要

背景

急性心肌梗死（AMI）患者的QT离散度增加，但QT离散度与预后的关系尚未完全阐明。

假说

本研究的目的是前瞻性评估QT离散度是否与AMI患者成功冠状动脉支架置入术后的主要不良心脏事件（MACE）风险及死亡率相关。

方法

本研究纳入了142例AMI且成功接受经皮冠状动脉介入治疗（PCI）的患者。在PCI术前及术后24小时测量校正QT离散度。

结果

在4477人月的随访期内，我们确认了21例MACE。单因素分析表明，PCI术前及术后24小时的校正QT离散度、年龄、Q波数量以及Killip分级≥2级与MACE及死亡率相关。多因素分析显示，PCI术前的校正QT离散度是MACE及死亡率的独立预测因素，但PCI术后24小时的校正QT离散度与MACE及死亡率无统计学关联。在校正年龄、性别、射血分数以及Killip分级≥2级后，PCI术前校正QT离散度每增加1个标准差（SD）幅度，MACE的多因素调整风险比为2.24（95%置信区间，1.36 - 3.68，p = 0.001），死亡率的多因素调整风险比为2.71（95%置信区间，1.50 - 4.89，p＜0.001）。

结论

AMI患者PCI术前的校正QT离散度与成功PCI术后MACE风险及死亡率增加相关。