Greenberger Paul A
Division of Allergy-Immunology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Suite 14018, 676 North St. Clair Street, Chicago, IL 60611, USA.
Immunol Allergy Clin North Am. 2007 May;27(2):273-93, vii-viii. doi: 10.1016/j.iac.2007.03.009.
Idiopathic anaphylaxis is a prednisone-responsive condition without external cause, but it can coexist with food-, medication-, or exercise-induced anaphylaxis. Mast cell activation may occur at night or after foods that have been eaten with impunity many times previously. Idiopathic anaphylaxis can be classified into frequent (if there are six or more episodes per year or two episodes in the last 2 months) or infrequent (if episodes occur less often). Idiopathic anaphylaxis-generalized consists of urticaria or angioedema associated with severe respiratory distress, syncope or hypotension, and gastrointestinal symptoms. Idiopathic anaphylaxis-angioedema consists of massive tongue enlargement or severe pharyngeal or laryngeal swelling with urticaria or peripheral angioedema. The differential diagnosis of idiopathic anaphylaxis is reviewed, and treatment approaches are presented.
特发性过敏反应是一种无外部诱因且对泼尼松有反应的病症，但它可与食物、药物或运动诱发的过敏反应同时存在。肥大细胞活化可能发生在夜间，或在之前多次食用均无不良反应的食物之后。特发性过敏反应可分为频发型（如果每年发作6次或更多次，或在过去2个月内发作2次）或偶发型（如果发作频率较低）。全身性特发性过敏反应包括伴有严重呼吸窘迫、晕厥或低血压以及胃肠道症状的荨麻疹或血管性水肿。血管性水肿型特发性过敏反应包括伴有荨麻疹或外周血管性水肿的巨舌或严重的咽喉部肿胀。本文对特发性过敏反应的鉴别诊断进行了综述，并介绍了治疗方法。
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