Kim Duk-Soo, Kim Ji-Eun, Kwak Sung-Eun, Kim Dae-Won, Choi Soo-Young, Kwon Oh-Shin, Kang Tae-Chon
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea.
Brain Res. 2007 Jun 18;1154:181-93. doi: 10.1016/j.brainres.2007.03.084. Epub 2007 Apr 3.
Since the correlation between the serotonin (5-hydroxytryptamine, 5-HT) system and seizure activity remains to be clarified, we investigated the 5-HT system in the hippocampus of seizure-resistant (SR) and seizure-sensitive (SS) gerbils. There was no difference of the 5-HT system in the hippocampi of young animals (predisposed and juvenile gerbils) in both SR and SS gerbils. 5-HT immunoreactivity in the dorsal raphe nucleus and the median raphe nucleus was also similarly detected in both animal groups. As compared to SR adult gerbils, only 5-HT1A receptor immunoreactivity was selectively reduced in CA1 interneurons within SS adult gerbils. (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (a 5-HT1A receptor agonist, 1 and 2 mg/kg) markedly reduced paired-pulse inhibition in the CA1 region of SS adult gerbils only. These findings suggest that the selective reduction in 5-HT1A receptor expression on CA1 interneurons of SS adult gerbil may not be developmental defects, but be an acquired compensatory change induced by repeated seizure activity.
由于血清素（5-羟色胺，5-HT）系统与癫痫发作活动之间的相关性仍有待阐明，我们研究了抗癫痫（SR）和癫痫敏感（SS）沙鼠海马中的5-HT系统。在SR和SS沙鼠的幼龄动物（易患癫痫和幼年沙鼠）海马中，5-HT系统没有差异。在两个动物组中，背侧中缝核和中缝正中核中的5-HT免疫反应性也同样被检测到。与SR成年沙鼠相比，仅在SS成年沙鼠的CA1中间神经元中5-HT1A受体免疫反应性选择性降低。（±）-8-羟基-2-（二正丙基氨基）四氢萘（一种5-HT1A受体激动剂，1和2mg/kg）仅显著降低了SS成年沙鼠CA1区的双脉冲抑制。这些发现表明，SS成年沙鼠CA1中间神经元上5-HT1A受体表达的选择性降低可能不是发育缺陷，而是由反复癫痫发作活动诱导的获得性代偿性变化。
