癫痫发作活动影响沙鼠海马体中的神经胶质Kv1通道免疫反应性。
Seizure activity affects neuroglial Kv1 channel immunoreactivities in the gerbil hippocampus.
作者信息
Kim Duk-Soo, Kim Ji-Eun, Kwak Sung-Eun, Won Moo Ho, Kang Tae-Cheon
机构信息
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, Kangwon-Do, South Korea.
出版信息
Brain Res. 2007 Jun 2;1151:172-87. doi: 10.1016/j.brainres.2007.03.017. Epub 2007 Mar 12.
In order to confirm the species-specific distribution of voltage-gated K(+) (Kv) channels and the definitive relationship between their immunoreactivities and seizure activity, we investigated Kv1 channel immunoreactivities in the hippocampus of seizure resistant (SR) and seizure sensitive (SS) gerbils. There was distinct difference of the Kv1 channel subtypes immunoreactivity in the hippocampi in both SR and SS gerbils. Kv1.1, Kv1.2, Kv1.3, Kv1.4, and Kv1.6 immunoreactivities in the SS gerbil hippocampus were lower than that in the SR gerbil hippocampus. However, Kv1 immunoreactivities were obviously presented in astrocyte within the stratum radiatum of the CA1 region of pre-seizure SS gerbil hippocampus. Following seizure-onset, Kv1 immunoreactivities (except Kv1.5) were markedly elevated, whereas their immunoreactivites in astrocytes were down-regulated. Therefore, the present study demonstrates that seizure activity may distinctly affect neuroglial Kv1 immunoreactivities in the gerbil hippocampus.
为了证实电压门控性钾离子（Kv）通道的物种特异性分布及其免疫反应性与癫痫发作活动之间的确切关系，我们研究了抗癫痫（SR）和癫痫敏感（SS）沙鼠海马中Kv1通道的免疫反应性。在SR和SS沙鼠的海马中，Kv1通道亚型的免疫反应性存在明显差异。SS沙鼠海马中Kv1.1、Kv1.2、Kv1.3、Kv1.4和Kv1.6的免疫反应性低于SR沙鼠海马。然而，在癫痫发作前的SS沙鼠海马CA1区辐射层内的星形胶质细胞中明显呈现Kv1免疫反应性。癫痫发作开始后，Kv1免疫反应性（除Kv1.5外）显著升高，而其在星形胶质细胞中的免疫反应性下调。因此，本研究表明癫痫发作活动可能明显影响沙鼠海马中神经胶质细胞的Kv1免疫反应性。
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