Oren Hüseyin, Erbay Ali R, Balci Mustafa, Cehreli Sengül
Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara.
Angiology. 2007 Apr-May;58(2):148-55. doi: 10.1177/0003319707300349.
Atherosclerosis is a dynamic chronic inflammatory process, and some inflammatory biomarkers have roles in this process. The levels of C-reactive protein (CRP) in patients with chronic stable coronary heart disease (CHD) have not been investigated well, and the levels of macrophage colony-stimulating factor (M-CSF) and interleukin-3 (IL-3) in patients with chronic stable CHD and the effects of these cytokines on atherogenesis are not known. To determine whether new inflammatory biomarkers have roles in atherosclerosis, the authors measured the levels of CRP, M-CSF, and IL-3 in patients with chronic stable CHD and in healthy controls. They measured plasma CRP concentrations by using a highly sensitive CRP reagent with immunonephelometric method, and plasma M-CSF and IL-3 concentrations with the help of a commercial enzyme-linked immunoassay test in 31 patients with chronic stable CHD documented by coronary angiography and in 22 age-matched healthy control subjects documented by coronary angiography. Mean plasma CRP, M-CSF, and IL-3 concentrations in patients with chronic stable CHD were significantly higher than those in controls (8.2 vs 4.6 mg/L, 195.3 vs 28.9 pg/mL, 173 vs 118 ng/mL, respectively, ppi.05). CRP, M-CSF, and IL-3 were all increased in patients with chronic stable CHD relative to controls. These findings suggest that these are new inflammatory biomarkers that may have important roles in the development of atherosclerotic lesions.
动脉粥样硬化是一个动态的慢性炎症过程，一些炎症生物标志物在这一过程中发挥作用。慢性稳定型冠心病（CHD）患者的C反应蛋白（CRP）水平尚未得到充分研究，慢性稳定型CHD患者的巨噬细胞集落刺激因子（M-CSF）和白细胞介素-3（IL-3）水平以及这些细胞因子对动脉粥样硬化形成的影响尚不清楚。为了确定新的炎症生物标志物是否在动脉粥样硬化中起作用，作者测量了慢性稳定型CHD患者和健康对照者的CRP、M-CSF和IL-3水平。他们采用免疫比浊法使用高敏CRP试剂测量血浆CRP浓度，并借助商业酶联免疫分析试验测量31例经冠状动脉造影证实为慢性稳定型CHD的患者和22例经冠状动脉造影证实的年龄匹配的健康对照者的血浆M-CSF和IL-3浓度。慢性稳定型CHD患者的平均血浆CRP、M-CSF和IL-3浓度显著高于对照组（分别为8.2 vs 4.6 mg/L、195.3 vs 28.9 pg/mL、173 vs 118 ng/mL，p<0.05）。相对于对照组，慢性稳定型CHD患者的CRP、M-CSF和IL-3均升高。这些发现表明，这些是新的炎症生物标志物，可能在动脉粥样硬化病变的发展中起重要作用。
